公开(公告)号：US09962384B1

公开(公告)日：2018-05-08

申请号：US15697728

申请日：2017-09-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yun Kyung Kim ,  Sung Su Lim ,  Do Hee Kim ,  Md. Mamunul Haque ,  Seul Gi Shin ,  Ha Eun Lee ,  Tae Hun Kim ,  Sang Min Lim ,  Ae Nim Pae

IPC: A61K31/50 ,  A61K47/36 ,  C07D237/10

CPC classification number: A61K31/50 ,  A61K47/36 ,  C07D237/04 ,  C07D237/10

Abstract: Disclosed is a levosimendan compound, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof, which is used for the prevention and/or treatment of diseases caused by tau aggregation or phosphorylation, such as neurodegenerative diseases (e.g., Alzheimer disease). In accordance with yet another aspect of the present invention, there is provided a health functional food for preventing or treating tau aggregation-related diseases, containing a levosimendan compound or a pharmaceutically acceptable salt, stereoisomer or solvate thereof.