公开(公告)号：US10442796B2

公开(公告)日：2019-10-15

申请号：US15998791

申请日：2018-08-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION

Inventor： Tae Bo Sim ,  Woo Young Hur ,  Chi Man Song ,  Ho Jong Yoon ,  Seung Hye Choi ,  Han Na Cho ,  Hwan Geun Choi ,  Nam Doo Kim ,  Jung Beom Son ,  Eun Hwa Ko ,  Hyun Kyoung Kim ,  Joong Heui Cho ,  Seock Yong Kang ,  So Young Kim ,  Yi Kyung Ko ,  Seung Yeon Lee ,  Suk Kyoon Yoon ,  Jae Hyun Bae

IPC: C07D409/12 ,  A61P35/02 ,  A61K31/381 ,  A61K31/4436 ,  C07D333/10 ,  C07D409/14

Abstract: The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

公开(公告)号：US20190047993A1

公开(公告)日：2019-02-14

申请号：US15998791

申请日：2018-08-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION

Inventor： Tae Bo Sim ,  Woo Young Hur ,  Chi Man Song ,  Ho Jong Yoon ,  Seung Hye Choi ,  Han Na Cho ,  Hwan Geun Choi ,  Nam Doo Kim ,  Jung Beom Son ,  Eun Hwa Ko ,  Hyun Kyoung Kim ,  Joong Heui Cho ,  Seock Yong Kang ,  So Young Kim ,  Yi Kyung Ko ,  Seung Yeon Lee ,  Suk Kyoon Yoon ,  Jae Hyun Bae

IPC: C07D409/12 ,  A61P35/02 ,  C07D409/14

CPC classification number: C07D409/12 ,  A61K31/381 ,  A61K31/4436 ,  A61P35/02 ,  C07D333/10 ,  C07D409/14 ,  Y02P20/55

Abstract: The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

公开(公告)号：US10155767B2

公开(公告)日：2018-12-18

申请号：US15672987

申请日：2017-08-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo Sim ,  Han Na Cho ,  Eun Hye Ju ,  Woo Young Hur ,  Ho Jong Yoon ,  Chi Man Song

IPC: C07D487/04

Abstract: The present invention provides a therapeutic agent of acute myeloid leukemia containing a 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one compound as an active ingredient, which has proliferation inhibitory activity for a human acute myeloid leukemia cell line OCI-AML3 having a NRAS mutant gene while having low inhibitory activity for wild type NRAS and has activity of inhibiting GCK and ACK1 protein kinases at the same time.