公开(公告)号：US20220087947A1

公开(公告)日：2022-03-24

申请号：US17384913

申请日：2021-07-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyojin LEE ,  Seongchan KIM ,  Youngdo JEONG

IPC: A61K9/51 ,  C12N9/22 ,  C12N15/11

Abstract: Provided are a surface-aminated mesoporous silica nanoparticle, a method of preparing the same, use of the nanoparticle for delivering a ribonucleoprotein, and use of the nanoparticle for the prevention or treatment of cancer. The surface-aminated mesoporous silica nanoparticle may be loaded with large RNPs such as Cas9-RNP, and thus may be applied to treatment of various diseases treatable by gene editing.

公开(公告)号：US20210130613A1

公开(公告)日：2021-05-06

申请号：US16855547

申请日：2020-04-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Youngdo JEONG ,  Kwan Hyi LEE ,  Hyojin LEE

IPC: C08L79/04 ,  C08G73/06 ,  A61K9/51

Abstract: Provided are positively charged nanoparticles and use thereof. According to the nanoparticles of an aspect, cucurbituril may limit electrostatic attraction between a guest for cucurbituril and a metal salt, thereby generating nanoparticles with a uniform size. Accordingly, the nanoparticles may have an effect of being capable of efficient intracellular gene delivery.