公开(公告)号：US20240002945A1

公开(公告)日：2024-01-04

申请号：US18038454

申请日：2021-11-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Youngdo JEONG ,  Ho Jun KIM ,  Sungwook PARK ,  Seongchan KIM

IPC: C12Q1/6886 ,  C12Q1/6837

CPC classification number: C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/156 ,  C12Q2600/178

Abstract: The present disclosure relates to a biosensor with surface-modified with reduced graphene oxide and a detection method using the same. The biosensor according to an aspect can effectively detect a target material in a urine sample, and thus, the use of the biosensor has an advantage in that prostate cancer can be diagnosed in a non-invasive, fast, and accurate manner.

公开(公告)号：US20220087947A1

公开(公告)日：2022-03-24

申请号：US17384913

申请日：2021-07-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyojin LEE ,  Seongchan KIM ,  Youngdo JEONG

IPC: A61K9/51 ,  C12N9/22 ,  C12N15/11

Abstract: Provided are a surface-aminated mesoporous silica nanoparticle, a method of preparing the same, use of the nanoparticle for delivering a ribonucleoprotein, and use of the nanoparticle for the prevention or treatment of cancer. The surface-aminated mesoporous silica nanoparticle may be loaded with large RNPs such as Cas9-RNP, and thus may be applied to treatment of various diseases treatable by gene editing.