公开(公告)号：US20180044674A1

公开(公告)日：2018-02-15

申请号：US15671901

申请日：2017-08-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gyo Chang KEUM ,  Eun Kyoung BANG ,  Jin Bum KIM

IPC: C12N15/113 ,  C07D495/04 ,  C07F3/06 ,  C07D213/38

CPC classification number: C12N15/113 ,  C07D213/38 ,  C07D495/04 ,  C07F3/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2320/51

Abstract: Provided herein are a novel Zn-DPA complex compound and an siRNA delivery system including the same as a transporter, the Zn-DPA complex compound including: a phosphate-directing functional part of zinc (II)-dipicolylamine (“Zn-DPA”); a cell membrane-directing functional part; and a linker part that links the phosphate-directing functional part and the cell membrane-directing functional part. The Zn-DPA complex compound has low toxicity and efficiently delivers siRNA to cells, thereby useful in various ways for various studies and diagnosis and treatment of diseases, which use siRNA.