公开(公告)号：US20180044674A1

公开(公告)日：2018-02-15

申请号：US15671901

申请日：2017-08-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gyo Chang KEUM ,  Eun Kyoung BANG ,  Jin Bum KIM

IPC: C12N15/113 ,  C07D495/04 ,  C07F3/06 ,  C07D213/38

CPC classification number: C12N15/113 ,  C07D213/38 ,  C07D495/04 ,  C07F3/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2320/51

Abstract: Provided herein are a novel Zn-DPA complex compound and an siRNA delivery system including the same as a transporter, the Zn-DPA complex compound including: a phosphate-directing functional part of zinc (II)-dipicolylamine (“Zn-DPA”); a cell membrane-directing functional part; and a linker part that links the phosphate-directing functional part and the cell membrane-directing functional part. The Zn-DPA complex compound has low toxicity and efficiently delivers siRNA to cells, thereby useful in various ways for various studies and diagnosis and treatment of diseases, which use siRNA.

公开(公告)号：US20210255203A1

公开(公告)日：2021-08-19

申请号：US17021438

申请日：2020-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo NAM ,  Hyun Ah CHOO ,  Ahmed A. Elbatrawy ,  Gyo Chang KEUM ,  Yun Kyung KIM ,  Sung Su LIM ,  Jae Kyun LEE ,  Eun Kyoung BANG

IPC: G01N33/68 ,  C07D215/20 ,  C07D401/06

Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

公开(公告)号：US20220233700A1

公开(公告)日：2022-07-28

申请号：US17617000

申请日：2020-05-25

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Hwan NAM ,  Gyo Chang KEUM ,  Hyo Jung PARK ,  Eun Kyoung BANG ,  Hae Li KO

IPC: A61K47/24 ,  A61K39/39 ,  A61K39/215 ,  C12N7/00 ,  C12N15/86 ,  A61K39/145 ,  A61P31/16 ,  A61K39/12 ,  A61P31/14

Abstract: The present disclosure relates to a pharmaceutical composition comprising a nucleic acid molecule of an adjuvant, a metal complex stabilizing the nucleic acid molecule, and optionally an immunogen that may be a peptide or a protein, or a composition of stabilizing the nucleic acid molecule of the adjuvant comprising the metal complex. The metal complex interacts with the nucleic acid molecule of the adjuvant and/or the immunogen so as to stabilize such pharmaceutically active ingredients, and induces continuous effectiveness of the active ingredients without degradation.