公开(公告)号：US20180057527A1

公开(公告)日：2018-03-01

申请号：US15687203

申请日：2017-08-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Gyo Chang KEUM ,  Eunice Eun Kyeong KIM ,  Sung Key JANG ,  Hee Sun KIM ,  Ae Nim PAE ,  Hua LI ,  Jin Hyeong PARK ,  Jin Sook KWAK

IPC: C07K5/065 ,  C07K5/062

Abstract: The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of consisting of a carbazole compound which shows excellent anti-proliferative efficacy against hepatitis C virus (HCV), a pharmaceutically acceptable salt thereof, a hydrate thereof, and an isomer thereof; an anti-virus pharmaceutical composition including the novel compound as an active ingredient; a pharmaceutical composition for preventing or treating liver diseases caused by hepatitis C virus; and a method of preparing the novel compound.

公开(公告)号：US20180044674A1

公开(公告)日：2018-02-15

申请号：US15671901

申请日：2017-08-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gyo Chang KEUM ,  Eun Kyoung BANG ,  Jin Bum KIM

IPC: C12N15/113 ,  C07D495/04 ,  C07F3/06 ,  C07D213/38

CPC classification number: C12N15/113 ,  C07D213/38 ,  C07D495/04 ,  C07F3/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2320/51

Abstract: Provided herein are a novel Zn-DPA complex compound and an siRNA delivery system including the same as a transporter, the Zn-DPA complex compound including: a phosphate-directing functional part of zinc (II)-dipicolylamine (“Zn-DPA”); a cell membrane-directing functional part; and a linker part that links the phosphate-directing functional part and the cell membrane-directing functional part. The Zn-DPA complex compound has low toxicity and efficiently delivers siRNA to cells, thereby useful in various ways for various studies and diagnosis and treatment of diseases, which use siRNA.

公开(公告)号：US20160244408A1

公开(公告)日：2016-08-25

申请号：US14629821

申请日：2015-02-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah CHOO ,  Gyo Chang KEUM ,  Youngjae KIM ,  MI Young YEOM

IPC: C07D209/86 ,  C07D401/06 ,  C07D413/06 ,  C07D403/06

CPC classification number: C07D209/86 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: Disclosed are carbazole derivatives and pharmaceutically acceptable salts thereof that act on the 5-HT7 receptor. The carbazole derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for the 5-HT7 serotonin receptor and antagonistic activities against the 5-HT7 serotonin receptor. Further disclosed are pharmaceutical compositions including the compounds as active ingredients. The pharmaceutical compositions are useful as therapeutic and prophylactic agents for central nervous system diseases where antagonistic activities against 5-HT7 are required, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, circadian rhythm dysregulation, sleep disturbance, and smooth muscle-related diseases.

Abstract translation: 公开了作用于5-HT 7受体的咔唑衍生物及其药学上可接受的盐。 咔唑衍生物及其药学上可接受的盐对5-HT7血清素受体具有高结合亲和力，对5-HT7血清素受体具有拮抗活性。 进一步公开了包含作为活性成分的化合物的药物组合物。 药物组合物可用作中枢神经系统疾病的治疗和预防剂，其中需要针对5-HT7的拮抗活性，例如抑郁症，偏头痛，焦虑症，疼痛，炎性疼痛，神经性疼痛，体温调节异常，昼夜节律紊乱，睡眠 干扰和平滑肌相关疾病。

公开(公告)号：US20210255203A1

公开(公告)日：2021-08-19

申请号：US17021438

申请日：2020-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo NAM ,  Hyun Ah CHOO ,  Ahmed A. Elbatrawy ,  Gyo Chang KEUM ,  Yun Kyung KIM ,  Sung Su LIM ,  Jae Kyun LEE ,  Eun Kyoung BANG

IPC: G01N33/68 ,  C07D215/20 ,  C07D401/06

Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

公开(公告)号：US20220233700A1

公开(公告)日：2022-07-28

申请号：US17617000

申请日：2020-05-25

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Hwan NAM ,  Gyo Chang KEUM ,  Hyo Jung PARK ,  Eun Kyoung BANG ,  Hae Li KO

IPC: A61K47/24 ,  A61K39/39 ,  A61K39/215 ,  C12N7/00 ,  C12N15/86 ,  A61K39/145 ,  A61P31/16 ,  A61K39/12 ,  A61P31/14

Abstract: The present disclosure relates to a pharmaceutical composition comprising a nucleic acid molecule of an adjuvant, a metal complex stabilizing the nucleic acid molecule, and optionally an immunogen that may be a peptide or a protein, or a composition of stabilizing the nucleic acid molecule of the adjuvant comprising the metal complex. The metal complex interacts with the nucleic acid molecule of the adjuvant and/or the immunogen so as to stabilize such pharmaceutically active ingredients, and induces continuous effectiveness of the active ingredients without degradation.

公开(公告)号：US20140343295A1

公开(公告)日：2014-11-20

申请号：US14013487

申请日：2013-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo NAM ,  Kyung Il CHOI ,  Ae Nim PAE ,  Seon Hee SEO ,  Hyun Ah CHOO ,  Gyo Chang KEUM ,  Jung Hyun KIM

IPC: C07D403/12

CPC classification number: C07D403/12 ,  A61K31/4155

Abstract: The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.

Abstract translation: 本发明涉及可用作钙通道阻滞剂的6-吡唑基氨基-3-取代的氮杂双环[3.1.0]己烷衍生物，其药学上可接受的盐，以及该化合物治疗疾病的钙通道抑制作用的医学用途。