公开(公告)号：US10557156B2

公开(公告)日：2020-02-11

申请号：US16026796

申请日：2018-07-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk Chung ,  Yu Hyun Ji ,  Jin Su An ,  Ick Chan Kwon ,  Eun Gyeong Yang

IPC: C12P19/12 ,  C12N9/16 ,  C12N9/14 ,  C12P7/64

Abstract: A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.

公开(公告)号：US20190010528A1

公开(公告)日：2019-01-10

申请号：US16026796

申请日：2018-07-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk Chung ,  Yu Hyun Ji ,  Jin Su An ,  Ick Chan Kwon ,  Eun Gyeong Yang

IPC: C12P19/12 ,  C12N9/16 ,  C12N9/14

Abstract: A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.