公开(公告)号：US20180169270A1

公开(公告)日：2018-06-21

申请号：US15845347

申请日：2017-12-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae Ro AHN ,  Jong Seong HA ,  Jong Bum LEE

IPC: A61K48/00 ,  C12N15/113 ,  C12N15/11

CPC classification number: A61K48/0058 ,  A61K9/0019 ,  A61K9/141 ,  A61K48/0025 ,  B82Y5/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2320/32

Abstract: Provided are a self-assembled polyribonucleotide-protein complex including a polyribonucleotide including a plurality of first repeating units having a single guide RNA (sgRNA) region and a small interfering RNA (siRNA) region; and one or more nuclease proteins binding to the sgRNA region, and use thereof.