公开(公告)号：US20180105852A1

公开(公告)日：2018-04-19

申请号：US15444605

申请日：2017-02-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae Ro AHN ,  Kyoung Ran KIM

IPC: C12P19/34 ,  C12N15/87 ,  C12N15/115

Abstract: Provided is a method of preparing nanoparticle-type polynucleotides, the method comprising forming the polynucleotides comprising modified nucleotides, in which the forming includes chemically synthesizing the polynucleotides comprising modified nucleotides, synthesizing the polynucleotides comprising modified nucleotides using an enzyme, or a combination thereof.

公开(公告)号：US20180169270A1

公开(公告)日：2018-06-21

申请号：US15845347

申请日：2017-12-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae Ro AHN ,  Jong Seong HA ,  Jong Bum LEE

IPC: A61K48/00 ,  C12N15/113 ,  C12N15/11

CPC classification number: A61K48/0058 ,  A61K9/0019 ,  A61K9/141 ,  A61K48/0025 ,  B82Y5/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2320/32

Abstract: Provided are a self-assembled polyribonucleotide-protein complex including a polyribonucleotide including a plurality of first repeating units having a single guide RNA (sgRNA) region and a small interfering RNA (siRNA) region; and one or more nuclease proteins binding to the sgRNA region, and use thereof.

公开(公告)号：US20160051483A1

公开(公告)日：2016-02-25

申请号：US14803343

申请日：2015-07-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae Ro AHN ,  Se Hoon KIM ,  Kyoung Ran KIM ,  Hyo Young KIM ,  Yong Deok LEE

IPC: A61K9/51 ,  A61K49/00 ,  A61K38/02 ,  A61K31/713 ,  A61K31/7088

CPC classification number: A61K9/513 ,  A61K9/0019 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/02 ,  A61K47/549 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0054

Abstract: The present invention relates to a molecule delivery technology and a carrier technology, which may selectively deliver a material to a desired specific cell and living tissue. The present invention may be utilized in the field of a drug carrier which effectively delivers an imaging probe and a therapeutic agent to an affected part.

Abstract translation: 本发明涉及分子递送技术和载体技术，其可以选择性地将材料递送到期望的特定细胞和活组织。 本发明可以用于有效地将成像探针和治疗剂输送到患部的药物载体领域。

公开(公告)号：US20140255307A1

公开(公告)日：2014-09-11

申请号：US14197322

申请日：2014-03-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae Ro AHN ,  Se Hoon KIM

IPC: A61K49/00

CPC classification number: A61K49/0093 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0054

Abstract: The present invention relates to contrast medium composition and a method of bio imagination using the same. The contrast medium composition of the present invention includes a biomolecule, DNA nanostructure, as an active ingredient, is fundamentally non-cytotoxic and non-immunogenic and is not likely to induce safety problems that may be observed in other organic or inorganic contrast medium composition. In addition, the contrast medium composition of the present invention not only facilitates diagnosis of disease through sufficient contrast enhancement effect by showing excellent cellular uptake and intracellular stability and can visualize even SLNs which is difficult to be visualized traditionally, so can judge metastasis of cancer easily and apply lower invasive treatment.

Abstract translation: 本发明涉及造影剂组合物和使用其的生物想象力的方法。 本发明的造影剂组合物包括作为活性成分的生物分子DNA纳米结构基本上是非细胞毒性和非免疫原性的，并且不可能引起可能在其它有机或无机造影剂组合物中观察到的安全问题。 此外，本发明的造影剂组合物不仅通过显示出优异的细胞摄取和细胞内稳定性而能够通过充分的对比度增强效果来促进疾病的诊断，并且可以使传统上难以被可视化的SLN甚至可视化，因此可以容易地判断癌症的转移 并应用低侵入性治疗。