公开(公告)号：US09458120B2

公开(公告)日：2016-10-04

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  A61K31/496 ,  C07D295/088 ,  C07D231/40 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D233/64 ,  C12N5/071 ,  C07D401/04 ,  C07D403/06 ,  C07D413/04 ,  A61K31/495 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 其中*表示（R） - 型或（S） - 型，X选自氢，卤素和具有1至4个碳原子的取代或未取代的直链或支链烷基，n表示X 和1〜5的整数，其中在具有1〜4个碳原子的取代的直链或支链烷基中至少有一个氢被卤素取代。 该衍生物可用于阻断T型钙通道和/或TREK通道，以及用于预防和/或治疗T型钙通道和/或TREK通道相关疾病。

公开(公告)号：US20150166496A1

公开(公告)日：2015-06-18

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  C07D233/64 ,  C12N5/071 ,  C07D211/58 ,  C07D211/52 ,  C07D295/088 ,  C07D211/22

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, use thereof for blocking T-type calcium channel and/or TREK channel, and use thereof for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 本发明涉及新的苯氧基丙醇衍生物，其用于阻断T型钙通道和/或TREK通道的用途及其用于预防和/或治疗T型钙通道和/或TREK通道相关疾病的用途。