公开(公告)号：US20150065494A1

公开(公告)日：2015-03-05

申请号：US14389609

申请日：2013-04-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dong Jin Kim ,  Kyung Ho Yoo ,  Young Soo Kim ,  Woong Seo Park ,  Yong Koo Kang ,  Hye Yun Kim ,  Yun Kyung Kim ,  Ki Duk Park ,  Maeng Sup Kim ,  Kwee Hyun Suh ,  Young Gil Ahn

IPC: C07D413/12 ,  C07D405/12 ,  C07D307/81

CPC classification number: C07D413/12 ,  C07D307/81 ,  C07D405/12

Abstract: The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.

Abstract translation: 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。