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1.发明授权公开(公告)号：US11592415B2
公开(公告)日：2023-02-28
申请号：US16070672
申请日：2016-10-20
Applicant: Korea Institute of Science and Technology
Inventor： Kyo Seon Hwang , Young Soo Kim , Jin Sik Kim , Yong Kyoung Yoo
IPC: G01N27/327 , G01N27/12 , G01N33/68 , G01N33/543 , C08L39/06 , C08L83/04
Abstract: The present invention relates to an interdigitated microelectrode biosensor using the reaction between receptors and target biomaterials, the interdigitated microelectrode biosensor comprising: an insulating layer formed so as to cover all of the sensor formation area of a substrate; a first interdigitated microelectrode formed such that a plurality of first protruding electrodes are arranged in a comb shape on the insulating layer of the substrate; a second interdigitated microelectrode, facing the first interdigitated microelectrode and formed such that a plurality of second protruding electrodes are arranged in a comb shape on the insulating layer of the substrate such that the plurality of second protruding electrodes are arranged to respectively interdigitate with the plurality of first protruding electrodes formed at the first interdigitated microelectrode; and a plurality of receptors arranged in the space between the first and second interdigitated microelectrodes, which are arranged to interdigitate with each other, so as to specifically react with the target biomaterial, thereby increasing an impedance detection width and detection limit, and improving detection accuracy according to the characteristics of each monomer and each polymer.
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公开(公告)号：US20180283198A1
公开(公告)日：2018-10-04
申请号：US15696331
申请日：2017-09-06
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： You Hwan Shin , Joo Hoon Park , Young Soo Kim
CPC classification number: F01D17/165 , F01D5/04 , F01D5/148 , F01D17/146 , F01D17/24
Abstract: The present disclosure is relates to a centrifugal turbo machine equipped with stretchable and variable diffuser vanes capable of securing further improvement of compression efficiency by reducing an angle of the vane and increasing a length of the vane using forced rotating driving of a diffuser during operation of a compressor so as to reduce frictional loss of the fluid when a flow rate of fluid is reduced.
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公开(公告)号：US10006920B2
公开(公告)日：2018-06-26
申请号：US14787146
申请日：2014-04-25
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Young Soo Kim , Dong Jin Kim , Hye Yun Kim , Soo Min Cho , Tae Song Kim , Hyunjin Kim , Sejin Lee , Kyoseon Hwang , Jee Hoon Roh , Jae-Young Koh
CPC classification number: G01N33/6893 , A61K38/1716 , C07K14/4711 , G01N33/6827 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of β-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.
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4.发明授权公开(公告)号：US10585105B2
公开(公告)日：2020-03-10
申请号：US15565503
申请日：2016-05-18
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Ji Yoon Kang , Kyeong Sik Shin , Jae Hoon Ji , Tae Song Kim , Young Soo Kim , Sang Yun Kim
Abstract: The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy.
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Patent Agency Ranking
公开(公告)号：US10352188B2
公开(公告)日：2019-07-16
申请号：US15696331
申请日：2017-09-06
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： You Hwan Shin , Joo Hoon Park , Young Soo Kim
Abstract: The present disclosure is relates to a centrifugal turbo machine equipped with stretchable and variable diffuser vanes capable of securing further improvement of compression efficiency by reducing an angle of the vane and increasing a length of the vane using forced rotating driving of a diffuser during operation of a compressor so as to reduce frictional loss of the fluid when a flow rate of fluid is reduced.
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公开(公告)号：US10975307B2
公开(公告)日：2021-04-13
申请号：US15865259
申请日：2018-01-09
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Munju Goh , Hyeonuk Yeo , Nam Ho You , Se Gyu Jang , Seokhoon Ahn , Young Soo Kim
IPC: G02F1/1333 , C09K19/38 , C09K19/12 , C09K19/30 , C09K19/32 , C09K19/22 , C09K19/16 , C09K19/24 , C09K19/34 , C09K19/20 , C09K19/04
Abstract: Disclosed is a liquid crystalline epoxy compound wherein an epoxy group is positioned at a side chain of the longer direction of a mesogen group and each of the mesogen group and the epoxy group is connected to the center of the molecular structure through a flexible linkage. Since the liquid crystalline epoxy compound includes an epoxy group positioned at a side chain of the longer direction of a mesogen group and each of the mesogen group and the epoxy group is connected to the center of the molecular structure through a flexible linkage, the interaction between the mesogens in a cured resin product occurs significantly without weakening even after curing, thereby improving the heat conductivity of the resin compound through the active heat transfer between the mesogens.
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7.发明授权Pharmaceutical composition for preventing or treating cognitive impairment-related disease comprising morpholine or piperazine based compounds, and donepezil 有权包含吗啉或哌嗪类化合物以及多奈哌齐的用于预防或治疗认知障碍相关疾病的药物组合物公开(公告)号：US09527824B2
公开(公告)日：2016-12-27
申请号：US14316963
申请日：2014-06-27
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Dong Jin Kim , Young Soo Kim , Hye Yun Kim , Hyun Jin Kim
IPC: A61K31/535 , C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
CPC classification number: C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
Abstract: Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N′(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.
Abstract translation: 提供了用于预防或治疗认知障碍相关疾病的药物组合物，所述药物组合物包括N-（2-羟乙基）哌嗪-N'（3-丙磺酸），其药学上可接受的盐或其衍生物，以及 多奈哌齐，其药学上可接受的盐或其衍生物。 该组合物可用于预防或治疗认知障碍相关疾病。
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8.发明申请AMINOSTYRYLBENZOFURAN DERIVATIVES AS INHIBITORS AGAINST BETA-AMYLOID FIBRIL FORMATION, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开作为抗β-淀粉样蛋白形成的抑制剂的氨基苯丙酮衍生物和包含其的药物组合物公开(公告)号：US20150065494A1
公开(公告)日：2015-03-05
申请号：US14389609
申请日：2013-04-01
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Dong Jin Kim , Kyung Ho Yoo , Young Soo Kim , Woong Seo Park , Yong Koo Kang , Hye Yun Kim , Yun Kyung Kim , Ki Duk Park , Maeng Sup Kim , Kwee Hyun Suh , Young Gil Ahn
IPC: C07D413/12 , C07D405/12 , C07D307/81
CPC classification number: C07D413/12 , C07D307/81 , C07D405/12
Abstract: The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.
Abstract translation: 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。
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9.发明申请PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING COGNITIVE IMPAIRMENT-RELATED DISEASE COMPRISING MORPHOLINE OR PIPERAZINE BASED COMPOUNDS, AND DONEPEZIL 有权用于预防或治疗包含吗啡或基于哌啶的化合物的认知性相关疾病的药物组合物和多西他赛公开(公告)号：US20150005306A1
公开(公告)日：2015-01-01
申请号：US14316963
申请日：2014-06-27
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Dong Jin KIM , Young Soo Kim , Hye Yun Kim , Hyun Jin Kim
IPC: C07D295/15 , C07D295/088 , A61K31/5375 , A61K31/445 , A61K31/495
CPC classification number: C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
Abstract: Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N′(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.
Abstract translation: 提供了用于预防或治疗认知障碍相关疾病的药物组合物，所述药物组合物包括N-（2-羟乙基）哌嗪-N'（3-丙磺酸），其药学上可接受的盐或其衍生物，以及 多奈哌齐，其药学上可接受的盐或其衍生物。 该组合物可用于预防或治疗认知障碍相关疾病。
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