公开(公告)号：US20210015931A1

公开(公告)日：2021-01-21

申请号：US16573351

申请日：2019-09-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Hwa KIM ,  Ick Chan KWON ,  In-San KIM ,  Kwangmeyung KIM ,  Yoosoo YANG ,  Young-Ji KO

IPC: A61K47/55 ,  A61K47/54 ,  A61K31/713 ,  A61P35/00 ,  C12N15/113 ,  C07K14/705

Abstract: A fusion protein-siRNA complex according to the present disclosure binds specifically to cancer cells, is taken up effectively by the cells, and exhibits anticancer activity as it is degraded by lysosomes. The fusion protein-siRNA complex provides maximized anticancer activity so that the cancer cells can be removed by autoimmunity, by inhibiting the immunity of the cancer cells and enhancing phagocytosis by macrophages.

公开(公告)号：US20200087705A1

公开(公告)日：2020-03-19

申请号：US16568363

申请日：2019-09-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Ick Chan KWON ,  Ju Hee RYU ,  Young-Ji KO ,  Hye-sun KIM ,  Nam-hyuk CHO ,  Eun-Jeong YANG ,  Jae Won LEE

IPC: C12Q1/37 ,  G01N33/573

Abstract: A probe for measuring the activity of caspase-1 according to the present disclosure can specifically image cells or tissues where inflammatory response is induced because it is cleaved by reacting specifically with the active caspase-1 enzyme in vivo and in vitro and re-emits fluorescence. The probe for measuring the activity of caspase-1 can be used for various purposes, such as for imaging of cells or tissues where inflammatory response is induced, as a drug carrier, for screening of a drug inhibiting inflammatory response, etc.The probe for measuring the activity of caspase-1 is applicable both in vivo and in vitro, and can be used for various applications such as high-throughput screening for new drug development, early diagnosis of diseases, etc.