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公开(公告)号：US20180292317A1
公开(公告)日：2018-10-11
申请号：US15574392
申请日：2016-05-16
Inventor： Sehoon KIM , Bong Hyun CHUNG , Youngsun KIM , Kyung Mi PARK , Young Hun SEO
IPC: G01N21/64
CPC classification number: G01N21/6428 , G01N33/582 , G01N2021/6439
Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
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Patent Agency Ranking
公开(公告)号：US20200016269A1
公开(公告)日：2020-01-16
申请号：US16395236
申请日：2019-04-26
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon KIM , Youngsun KIM , Keunsoo JEONG , Gayoung KIM
Abstract: The present invention relates to near-infrared-absorbing dye-based composite particles which exhibit a photothermal effect and/or photoacoustic signal upon photoirradiation, a preparation method thereof, and a use thereof. The near-infrared-absorbing composite particles comprise: a water-insoluble salt of a near-infrared-absorbing dye, which comprises anions of the near-infrared-absorbing dye and metal cations capable of forming a precipitation product with the anions of the near-infrared-absorbing dye; and particles of a polymeric surfactant, in which a water-insoluble salt of the near-infrared-absorbing dye is supported in the hydrophobic part of the polymeric surfactant.
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公开(公告)号：US20210041359A1
公开(公告)日：2021-02-11
申请号：US16935687
申请日：2020-07-22
Inventor： Sehoon KIM , Bong Hyun CHUNG , Youngsun KIM , Kyung Mi PARK , Young Hun SEO
Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
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4.发明申请公开(公告)号：US20190076554A1
公开(公告)日：2019-03-14
申请号：US16034898
申请日：2018-07-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon KIM , Myung KIM , Young Hun SEO , Jungyun HEO , Youngsun KIM
IPC: A61K49/00
Abstract: The present invention relates to a nanocomposite for detecting hydrogen sulfide; a method for preparing the same; a novel reactive fluorogenic compound to be used in the method; a kit for detecting hydrogen sulfide comprising the nanocomposite; and a method for providing information for the diagnosis of a disease, which causes abnormal secretion of hydrogen sulfide, by using the nanocomposite.
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5.发明申请公开(公告)号：US20170209373A1
公开(公告)日：2017-07-27
申请号：US15361996
申请日：2016-11-28
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon KIM , Youngsoo KIM , Youngsun KIM , Keunsoo JEONG , Ajay SINGH
CPC classification number: A61K31/12 , A61K9/0019 , A61K9/5146 , A61K49/0021 , A61K49/0093
Abstract: The present invention relates to a drug delivery system (DDS) for crossing the blood-brain barrier (BBB) formed by self-assembly of an amphiphilic block copolymer, comprising a self-assembled structure having an average diameter of 5 nm to 20 nm of a core-shell structure comprising a hydrophobic core and a hydrophilic shell; and a hydrophobic drug supported in the hydrophobic core of the self-assembled structure, a pharmaceutical composition for preventing or treating cerebral diseases comprising the drug delivery system as an active ingredient, and a preparation method of the drug delivery system.
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6.发明申请METHYLENE BLUE NANOPARTICLE FOR BIOIMAGING AND PHOTODYNAMIC THERAPY AND USE THEREOF 审中-公开用于生物转化和光化学治疗的亚甲基蓝色纳米颗粒及其用途公开(公告)号：US20150273084A1
公开(公告)日：2015-10-01
申请号：US14667935
申请日：2015-03-25
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon KIM , Ick Chan KWON , Sangyoup LEE
CPC classification number: A61K41/0057 , A61K9/1075 , A61K9/5123 , A61K9/5146 , A61K49/003 , A61K49/0082
Abstract: The present invention relates to a methylene blue nanoparticle for bioimaging and photodynamic therapy, and a use thereof as a cancer therapeutic agent and a contrast agent. The methylene blue nanoparticle of the present invention for use as a topical cancer targeting photo therapeutic agent is composed of only a material of which the composition is clinically used or derived from human bodies, and thus a nanopreparation in which a barrier to clinical entry is low and the possibility of commercialization is very high, exhibits near-infrared fluorescence along with cancer targeting property, capacity of generating singlet oxygen and the like, and thus may be used for both bioimaging diagnosis such as optical imaging, and cancer targeting photodynamic therapy.
Abstract translation: 本发明涉及用于生物成像和光动力学治疗的亚甲基蓝纳米颗粒及其作为癌症治疗剂和造影剂的用途。 用作局部癌症靶向光疗法的本发明的亚甲基蓝纳米颗粒仅由组合物临床使用或衍生自人体的材料组成，因此其中临床进入的障碍低的纳米制备 并且商品化的可能性非常高，显示近红外荧光以及癌靶向性，产生单线态氧的能力等，因此可用于生物成像诊断例如光学成像和癌症靶向光动力疗法。
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