公开(公告)号：US20180133305A1

公开(公告)日：2018-05-17

申请号：US15574274

申请日：2015-09-14

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Dae Gwin JEONG ,  Dae Sub SONG ,  Sun Woo YOON

IPC: A61K39/145 ,  A61K39/395 ,  C07K14/11 ,  C07K16/10 ,  A61P31/16

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/395 ,  A61K2039/54 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  A61P31/16 ,  C07K14/005 ,  C07K14/11 ,  C07K16/10 ,  C07K16/1018 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: The present invention relates to a versatile influenza virus vaccine composition using the HA2 helical domain of a hemagglutinin protein, which is an influenza surface protein, and to a pharmaceutical composition for preventing or treating influenza virus infectious diseases. The polypeptide expressed by SEQ ID NO: 3 and the polypeptide expressed by residues 379 to 474 of SEQ ID NO: 1 of the present invention can be mass-produced in E. coli, and effectively produce neutralizing antibodies to various influenza virus subtypes, and thus the polypeptides can be widely utilized as versatile vaccines for influenza virus subtypes and new influenza virus variants.