专利检索 ap:("KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY") AND inv:"Joon Sung HWANG" 第 1 页

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发明申请
NOVEL INDOLE DERIVATIVE AND ANTI-CANCER CONPOSITION CONTAINING SAME 有权

公开(公告)号：US20210292306A1

公开(公告)日：2021-09-23

申请号：US15999066

申请日：2017-02-13

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Bo Yeon KIM , Nak Kyun SOUNG , Srinivas Rao GANIPISETTI , Jong Seog AHN , Jae-Hyuk JANG , Sung-kyun KO , In Ja RYOO , Hyunjoo CHA , Joon Sung HWANG , Kyung Ho LEE

IPC分类号： C07D405/12 , A61K8/49 , A23L29/00 , A61Q19/00 , A61K31/404 , A61P35/00 , A61K9/00

摘要： The present invention relates to: an indole derivative, which is a novel cell mitosis inhibitor; a stereoisomer thereof or a pharmaceutically acceptable salt thereof; a use thereof as a therapeutic agent; a composition containing the same and a treatment method using the composition; and a preparation method therefor. According to the present invention, the indole derivative, the stereoisomer thereof or the pharmaceutically acceptable salt thereof, inhibits the tubulin polymerization during mitosis so as to induce apoptosis, and has an excellent anti-cancer effect also in cancer cells having multiple drug resistance.