公开(公告)号：US10695390B2

公开(公告)日：2020-06-30

申请号：US16060780

申请日：2016-12-09

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Chul Ho Lee ,  Yong-Hoon Kim ,  Jung Ran Noh ,  Dong Hui Choi ,  Jung Hwan Hwang ,  Kyoung Shim Kim ,  Yun-Jung Seo ,  In-Bok Lee ,  Jung-Hyeon Choi

IPC: A61K36/428 ,  A61K36/42 ,  A23K10/30 ,  A23L33/105 ,  A61P1/16

Abstract: The present invention relates to: a composition comprising a Sicyos angulatus extract or a fraction thereof as an effective ingredient for preventing, alleviating, or treating liver diseases; and a method for preventing or treating liver diseases, comprising a step of administering the composition to a subject suspected of having a liver disease.

公开(公告)号：US20140142173A1

公开(公告)日：2014-05-22

申请号：US14009526

申请日：2011-11-28

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Won Gon Kim ,  Baek Soo Han ,  Kyoung Shim Kim ,  Kwang Soo Kim ,  Young Mi Kang ,  Yu Jin Kim ,  Chun Hyung Kim ,  Mi Jin Sohn ,  Hoe Yune Jung

IPC: A61K31/357 ,  A61K36/83

CPC classification number: A61K31/357 ,  A61K36/83

Abstract: The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the composition comprises an active ingredient in the form of genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; or a functional food additive for preventing or alleviating a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the additive comprises genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; and a method for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the method comprises the step of administering the pharmaceutical composition.

Abstract translation: 本发明涉及：用于预防或治疗神经退行性疾病或由Nurr1功能受损引起的疾病的药物组合物或Nurr1活化组合物，其中所述组合物包含以genkwanin N或元花胺形式的活性成分，达芙妮 genkwa提取物包含一种或多种上述化合物或其一部分; 或用于预防或减轻神经退行性疾病或由Nurr1功能受损引起的疾病的功能性食品添加剂，其中所述添加剂包括genkwanin N或元华辛，包含一种或多种上述化合物的Daphne genkwa提取物或其一部分; 以及用于预防或治疗由Nurr1功能受损引起的神经变性疾病或疾病的方法，其中所述方法包括施用所述药物组合物的步骤。