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公开(公告)号：US10792323B2
公开(公告)日：2020-10-06
申请号：US16349762
申请日：2017-11-13
Inventor： Won Gon Kim , Baek Soo Han , Jeong Su Byun , Ha Young Choi
Abstract: The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.
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公开(公告)号：US11738063B2
公开(公告)日：2023-08-29
申请号：US17012238
申请日：2020-09-04
Inventor： Won Gon Kim , Baek Soo Han , Jeong Su Byun , Ha Young Choi
Abstract: The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.
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公开(公告)号：US10760051B2
公开(公告)日：2020-09-01
申请号：US15506626
申请日：2015-08-13
Inventor： Baek Soo Han , Sang Chul Lee , Kwang-Hee Bae , Cheonok Lee , Won Kon Kim , Kyoung Jin Oh
IPC: C12N5/079
Abstract: The present invention relates to a method for producing astrocytes comprising obtaining neural progenitor cells from stem cells so as to continuously produce astrocytes with high purity and same traits, followed by two steps of differentiating the neural progenitor cells into the astrocytes, and astrocytes produced therefrom. Since the method of preparing the astrocytes provided in the present invention enables not only production of the astrocytes with high purity and faster production of the astrocytes with same characteristics, but also rapid differentiation of the astrocytes using the neural progenitor cells when necessary, it can be widely used for effectively treating a patient with a disease which requires transplantation of the astrocytes.
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Patent Agency Ranking
公开(公告)号：US12226395B2
公开(公告)日：2025-02-18
申请号：US17811327
申请日：2022-07-08
Inventor： Won Gon Kim , Baek Soo Han , Jeong Su Byun , Van Minh Nguyen , Ha Young Choi
IPC: A61K31/36 , A23L33/105 , A61K31/232
Abstract: The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof. Specifically, the diterpene of the present invention can prevent or treat neurodegenerative diseases caused by inhibition of Nurr1 activity by activating Nurr1 and inhibiting the inflammatory response.
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公开(公告)号：US10231999B2
公开(公告)日：2019-03-19
申请号：US15506216
申请日：2015-08-13
Inventor： Sang Chul Lee , Baek Soo Han , Kwang-Hee Bae , Hyejin Kim , Won Kon Kim , Kyoung Jin Oh
Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.
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6.发明申请PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF A NEURODEGENERATIVE DISEASE, COMPRISING A DAPHNE GENKWA EXTRACT OR A COMPOUND ISOLATED THEREFROM 有权用于预防或治疗神经病变疾病的药物组合物，包含狄氏酵母提取物或其分离的化合物公开(公告)号：US20140142173A1
公开(公告)日：2014-05-22
申请号：US14009526
申请日：2011-11-28
Inventor： Won Gon Kim , Baek Soo Han , Kyoung Shim Kim , Kwang Soo Kim , Young Mi Kang , Yu Jin Kim , Chun Hyung Kim , Mi Jin Sohn , Hoe Yune Jung
IPC: A61K31/357 , A61K36/83
CPC classification number: A61K31/357 , A61K36/83
Abstract: The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the composition comprises an active ingredient in the form of genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; or a functional food additive for preventing or alleviating a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the additive comprises genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; and a method for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the method comprises the step of administering the pharmaceutical composition.
Abstract translation: 本发明涉及：用于预防或治疗神经退行性疾病或由Nurr1功能受损引起的疾病的药物组合物或Nurr1活化组合物，其中所述组合物包含以genkwanin N或元花胺形式的活性成分，达芙妮 genkwa提取物包含一种或多种上述化合物或其一部分; 或用于预防或减轻神经退行性疾病或由Nurr1功能受损引起的疾病的功能性食品添加剂，其中所述添加剂包括genkwanin N或元华辛，包含一种或多种上述化合物的Daphne genkwa提取物或其一部分; 以及用于预防或治疗由Nurr1功能受损引起的神经变性疾病或疾病的方法，其中所述方法包括施用所述药物组合物的步骤。
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公开(公告)号：US20170267971A1
公开(公告)日：2017-09-21
申请号：US15506626
申请日：2015-08-13
Inventor： Baek Soo Han , Sang Chul Lee , Kwang-Hee Bae , Cheonok Lee , Won Kon Kim , Kyoung Jin Oh
IPC: C12N5/079
Abstract: The present invention relates to a method for producing astrocytes comprising obtaining neural progenitor cells from stem cells so as to continuously produce astrocytes with high purity and same traits, followed by two steps of differentiating the neural progenitor cells into the astrocytes, and astrocytes produced therefrom. Since the method of preparing the astrocytes provided in the present invention enables not only production of the astrocytes with high purity and faster production of the astrocytes with same characteristics, but also rapid differentiation of the astrocytes using the neural progenitor cells when necessary, it can be widely used for effectively treating a patient with a disease which requires transplantation of the astrocytes.
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公开(公告)号：US20170266235A1
公开(公告)日：2017-09-21
申请号：US15506216
申请日：2015-08-13
Inventor： Sang Chul Lee , Baek Soo Han , Kwang-Hee Bae , Hyejin Kim , Won Kon Kim , Kyoung Jin Oh
IPC: A61K35/30 , C12N5/0793 , C12N5/10 , A61K38/17 , C12N5/074
CPC classification number: A61K35/30 , A61K38/1787 , A61K45/00 , A61K48/00 , C12N5/00 , C12N5/0607 , C12N5/0619 , C12N5/10 , C12N2502/08
Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.
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