公开(公告)号：US20210392863A1

公开(公告)日：2021-12-23

申请号：US17288045

申请日：2019-10-23

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sun Uk KIM ,  Young Ho PARK ,  Kyu Tae CHANG ,  Bo Woong SIM ,  Bong Seok SONG ,  Hae Jun YANG ,  Sang Rae LEE ,  Kang Jin JEONG ,  Pil Soo JEONG ,  Yeung Bae JIN ,  Phil Yong KANG ,  Seung Hwan LEE ,  Hwal Yong LEE ,  Kyung Seob LIM ,  Young Hyun KIM ,  Ji Su KIM ,  Han Na KIM ,  Hee Chang SON ,  Seung Bin YOON ,  Jong Hee LEE ,  Seon A CHOI ,  Jae Won HUH

IPC: A01K67/027 ,  C12N15/11 ,  C12N9/22 ,  C12N15/85

Abstract: The present disclosure relates to a dwarfism animal model carrying an IGF-1 gene mutation and a method for generating the same. According to the present disclosure, the problem that an animal dies immediately after birth is overcome, the majority of phenotypes seen in Laron syndrome patients may be observed in the dwarfism animal model, and the dwarfism animal model has decreased expression of personality genes. Thus, the dwarfism animal model may be effectively used as a dwarfism-related disease model.