公开(公告)号：US20240008460A1

公开(公告)日：2024-01-11

申请号：US18034995

申请日：2021-10-15

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sun Uk KIM ,  Young Ho PARK ,  Bo Woong SIM ,  Kyu Tae CHANG ,  Seung Hwan LEE ,  Bong Seok SONG ,  Pil Soo JEONG ,  Hae Jun YANG ,  Sang Rae LEE ,  Yeung Bae JIN ,  Kang Jin JEONG

IPC: A01K67/027 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC classification number: A01K67/0276 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  A01K2227/108 ,  A01K2217/075 ,  A01K2217/054 ,  A01K2267/0387 ,  C12N2310/20

Abstract: The present disclosure relates to a JAK3 gene-mutated severe combined immunodeficiency animal model and a method of constructing the same. In the JAK3 gene-mutated severe combined immunodeficiency animal model of the present disclosure, the JAK3 gene is specifically deficient, the expression of cytokines is regulated by controlling the number and activity of macrophages, and the thymus, lymphocytes, and Peyer's patches, which are observed in conventional severe combined immunodeficiency animal models, particularly mini-pigs, are completely lacking. In addition, the animal model of the present disclosure can be used as a treatment model for JAK3 SCID patients, as similar phenotypes are observed in patients with human severe combined immunodeficiency caused by a JAK3 gene mutation, and can be used for artificial blood development or xenotransplantation.

公开(公告)号：US20180322336A1

公开(公告)日：2018-11-08

申请号：US15779913

申请日：2016-11-30

Applicant: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sang Kuy HAN ,  Keyoung Jin CHUN ,  Kyu Tae CHANG ,  Young Jeon LEE ,  Yeung Bae JIN ,  Kang jin JEONG ,  Phil Yong KANG ,  Jung Joo HONG ,  Sang Rae LEE

IPC: G06K9/00 ,  G06T7/73 ,  G06T7/593 ,  H04N13/204

Abstract: The present invention includes: a three-dimensional moving image generation module for generating a moving image of an experiment target person; an object extraction module for extracting the experiment target person, separately from a background, from the moving image; an object definition module for defining an object by measuring a length, a size and a weight center of the object and extracting a depth image of the object; a behaviour pattern definition module for defining a basic behaviour pattern of the object by cumulatively analyzing a movement speed and movement time of the weight center of the corresponding object, and changes in the extracted depth data when the object defined by the object definition module is extracted by the object extraction module; and a behaviour pattern analysis module for analyzing and identifying a lasting time and a frequency of the basic behaviour pattern with respect to the object.

公开(公告)号：US20210392863A1

公开(公告)日：2021-12-23

申请号：US17288045

申请日：2019-10-23

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sun Uk KIM ,  Young Ho PARK ,  Kyu Tae CHANG ,  Bo Woong SIM ,  Bong Seok SONG ,  Hae Jun YANG ,  Sang Rae LEE ,  Kang Jin JEONG ,  Pil Soo JEONG ,  Yeung Bae JIN ,  Phil Yong KANG ,  Seung Hwan LEE ,  Hwal Yong LEE ,  Kyung Seob LIM ,  Young Hyun KIM ,  Ji Su KIM ,  Han Na KIM ,  Hee Chang SON ,  Seung Bin YOON ,  Jong Hee LEE ,  Seon A CHOI ,  Jae Won HUH

IPC: A01K67/027 ,  C12N15/11 ,  C12N9/22 ,  C12N15/85

Abstract: The present disclosure relates to a dwarfism animal model carrying an IGF-1 gene mutation and a method for generating the same. According to the present disclosure, the problem that an animal dies immediately after birth is overcome, the majority of phenotypes seen in Laron syndrome patients may be observed in the dwarfism animal model, and the dwarfism animal model has decreased expression of personality genes. Thus, the dwarfism animal model may be effectively used as a dwarfism-related disease model.