公开(公告)号：US20210332029A1

公开(公告)日：2021-10-28

申请号：US17268869

申请日：2019-08-12

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho Lee ,  Gildon Choi ,  Seoyoung Lee ,  Jiwon Kim ,  Byoung Chul Cho ,  Chae Won Park ,  Jiyeon Yun

IPC: C07D403/06 ,  C07D471/04 ,  C07D403/14 ,  C07D401/14 ,  A61K45/06

Abstract: The present invention relates to an isoindolin-1-on derivative, a method for preparing same, and a pharmaceutical composition comprising same as an effective component for preventing or treating tumors, wherein the isoindolin-1-on derivative exhibits a high inhibitory effect on EGFR mutations, and thus can be beneficially used for the treatment of EGFR-mutated tumors, and the isoindolin-1-on derivative exhibits a significant synergistic effect when co-administered, and thus can be beneficially used in concomitant therapy.

公开(公告)号：US11976059B2

公开(公告)日：2024-05-07

申请号：US17268869

申请日：2019-08-12

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho Lee ,  Gildon Choi ,  Seoyoung Lee ,  Jiwon Kim ,  Byoung Chul Cho ,  Chae Won Park ,  Jiyeon Yun

IPC: C07D401/14 ,  A61K45/06 ,  C07D403/06 ,  C07D403/14 ,  C07D471/04

CPC classification number: C07D403/06 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04

Abstract: The present invention relates to an isoindolin-1-on derivative, a method for preparing same, and a pharmaceutical composition comprising same as an effective component for preventing or treating tumors, wherein the isoindolin-1-on derivative exhibits a high inhibitory effect on EGFR mutations, and thus can be beneficially used for the treatment of EGFR-mutated tumors, and the isoindolin-1-on derivative exhibits a significant synergistic effect when co-administered, and thus can be beneficially used in concomitant therapy.