公开(公告)号：US20240252488A1

公开(公告)日：2024-08-01

申请号：US18246773

申请日：2021-09-27

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  HUONS CO., LTD.

Inventor： Jong Yeon HWANG ,  Hyunjun KIM ,  Hyowon MUN ,  Hyun Jin KIM ,  Jae Du HA ,  Sung Yun CHO ,  Chang Soo YUN ,  Pilho KIM ,  Jisoo LEE ,  Joon Gyo OH

IPC: A61K31/497 ,  A61K31/4439 ,  A61K31/444 ,  A61K47/54 ,  A61K47/55 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

CPC classification number: A61K31/497 ,  A61K31/4439 ,  A61K31/444 ,  A61K47/545 ,  A61K47/55 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

Abstract: The present disclosure provides a compound of a specific chemical structure binding to MLKL or having an MLKL inhibiting or degrading activity, or pharmaceutically acceptable salts thereof. The present disclosure provides a composition comprising such compound or pharmaceutically acceptable salts thereof. The present disclosure provides the pharmaceutical use of the compound according to the present invention, salts thereof, and a composition comprising same for treating or preventing MLKL-related diseases. The present disclosure also provides a method for treating or preventing MLKL-related diseases, comprising administering to a subject in need of treatment an effective amount of a compound according to the present invention, salts thereof, or a composition comprising same.