公开(公告)号：US11298534B2

公开(公告)日：2022-04-12

申请号：US16235498

申请日：2018-12-28

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  Korea University Research and Business Foundation, Sejong Campus

Inventor： Hoon Jai Chun ,  Jung Hwa Hong ,  Dong Geun Sul ,  Bora Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61B17/00

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

公开(公告)号：US20190321631A1

公开(公告)日：2019-10-24

申请号：US16235498

申请日：2018-12-28

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Hoon Jai Chun ,  Jung Hwa Hong ,  Dong Geun Sul ,  Bora Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim

IPC: A61N1/36 ,  A61N1/372 ,  A61N1/05

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

公开(公告)号：US12023483B2

公开(公告)日：2024-07-02

申请号：US17609388

申请日：2020-03-19

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Hoon Jai Chun ,  Bo Ra Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim ,  Jae Min Lee

IPC: A61N1/08 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0509 ,  A61N1/08 ,  A61N1/36007

Abstract: An electrical stimulation device according to an embodiment includes: an elongated element having working channels; a plurality of electrical stimulators each including a longitudinal member extending along the longitudinal direction of the working channel, and a tip which is installed at the distal end of the longitudinal member and configured to apply electrical stimulation to a subject; and a control unit that independently controls the plurality of electrical stimulators to vary the range of electric stimulation applied to the subject.

公开(公告)号：US09248202B2

公开(公告)日：2016-02-02

申请号：US14463116

申请日：2014-08-19

Applicant: Korea University Research and Business Foundation ,  SFC CO., LTD.

Inventor： Bong-Rae Cho ,  Dong Eun Kang ,  Chang Su Lim ,  Ji Yeon Kim ,  Eun Sun Kim ,  Hoon Jai Chun

IPC: C07D405/14 ,  C12Q1/02 ,  A61K49/00 ,  C07D401/14

CPC classification number: A61K49/0052 ,  A61K49/0039 ,  C07D401/14 ,  C07D405/14 ,  C12Q1/02 ,  G01N33/57419

Abstract: The present disclosure relates to a two-photon probe for in-vivo imaging, having high selectivity for copper(II) ion, and a method for quantitatively estimating copper(II) on (Cu2+) in vivo using the same. The two-photon probe according to the present disclosure can detect intracellular free copper(II) on for a long period of time with a penetration depth greater than 90 μm in living cells and tissues without the problems of mistargeting and photobleaching and can quantitatively estimate copper(II) on concentration in vivo using the ratio of blue emission intensity at 400-450 nm and red emission intensity at 550-650 nm.

Abstract translation: 本公开内容涉及用于体内成像的双光子探针，其具有对铜（II）离子的高选择性，以及使用其对体内（Cu 2+）上的铜（II）进行定量估计的方法。 根据本公开的双光子探针可以在活细胞和组织中长时间检测细胞内游离铜（II），穿透深度大于90μm，而不会发生靶向和光漂白的问题，并且可以定量估计铜 （II）使用400-450nm的蓝色发射强度与550-650nm处的红色发射强度的比例。

公开(公告)号：US09220794B2

公开(公告)日：2015-12-29

申请号：US14459944

申请日：2014-08-14

Applicant: Korea University Research and Business Foundation

Inventor： Bong-Rae Cho ,  Chang Su Lim ,  Sajal Kumar Das ,  Sun Young Yang ,  Eun Sun Kim ,  Hoon Jai Chun

IPC: A61K49/00 ,  C07D277/66

CPC classification number: A61K49/0021 ,  C07D277/66

Abstract: The present disclosure relates to a two-photon fluorescent dye for imaging total sulfide in vivo and a method for quantitatively estimating total sulfide concentration in vivo using the same. The two-photon fluorescent dye, which includes a compound of [Chemical Formula 1], can detect hydrosulfide ion and image total sulfide and allows quantitative estimation of total sulfide concentration in vivo.

Abstract translation: 本公开内容涉及用于在体内成像总硫化物的双光子荧光染料和使用其同时量化体内总硫化物浓度的方法。 包含[化学式1]的化合物的双光子荧光染料可以检测氢硫化物离子和图像总硫化物，并允许定量估计体内总硫化物浓度。

公开(公告)号：US20230256237A1

公开(公告)日：2023-08-17

申请号：US18022487

申请日：2021-07-16

Applicant: Korea University Research and Business Foundation

Inventor： Hoon Jai Chun ,  Seung Han Kim ,  Bo Ra Keum ,  Hyuk Soon Choi ,  Eun Sun Kim

IPC: A61N1/05

CPC classification number: A61N1/0517 ,  A61N1/36007

Abstract: An electrical stimulation system according to an embodiment may comprise: a catheter having a long and thin tubular shape; an electrode disposed at one end of the catheter and inserted into a target portion; an electrical stimulator for generating electrical stimulation to be applied onto the target portion by the electrode; and a control part for controlling an electrical pulse of the electrical stimulator to change the electrical stimulation applied onto the target portion, wherein the electrode applies electrical stimulation in a state where a distal end of the electrode is enlarged and fixed to a target portion.

公开(公告)号：US20220218984A1

公开(公告)日：2022-07-14

申请号：US17609388

申请日：2020-03-19

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Hoon Jai Chun ,  Bo Ra Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim ,  Jae Min Lee

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/08

Abstract: An electrical stimulation device according to an embodiment includes: an elongated element having working channels; a plurality of electrical stimulators each including a longitudinal member extending along the longitudinal direction of the working channel, and a tip which is installed at the distal end of the longitudinal member and configured to apply electrical stimulation to a subject; and a control unit that independently controls the plurality of electrical stimulators to vary the range of electric stimulation applied to the subject.