公开(公告)号：US20240084259A1

公开(公告)日：2024-03-14

申请号：US17767822

申请日：2019-11-13

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Do-Sun LIM ,  Seung Cheol CHOI ,  Hyung Joon JOO ,  Jong-Ho KIM ,  Chi-Yeon PARK ,  Yongdoo PARK

IPC: C12N5/077 ,  C12N5/00 ,  G01N33/50 ,  G01N33/68

CPC classification number: C12N5/0657 ,  C12N5/0018 ,  G01N33/5061 ,  G01N33/6887 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/119 ,  C12N2503/02 ,  G01N2333/805

Abstract: The present invention relates to stem cell-derived mature cardiomyocytes and a cardiovascular disease model using same and, more specifically, to differentiation into mature ventricular cardiomyocytes by culturing stem cells in a medium containing FGF4 and ascorbic acid, and use of the differentiated mature ventricular cardiomyocytes as a cardiovascular disease cell model. The mature ventricular cardiomyocytes, obtained by culturing stem cells in a medium containing FGF4 and ascorbic acid and inducing the differentiation thereof, and cardiovascular disease cell model using same according to the present invention are very useful for screening for cardiovascular disease therapeutic agents and evaluation of the toxicity of new drugs.