公开(公告)号：US20170095579A1

公开(公告)日：2017-04-06

申请号：US15335896

申请日：2016-10-27

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Young Keun KIM ,  Jun Hua WU ,  Ji Hyun MIN ,  Ji-Sung LEE ,  Jae-Ho JUNG ,  Woo Seung HAM

IPC: A61K49/18 ,  G01N27/72 ,  C01G45/12 ,  G01N33/58 ,  A61K49/16

CPC classification number: G01N27/72 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/0058 ,  A61K49/0093 ,  C01G45/12 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2006/42 ,  G01N33/5375 ,  G01N33/5434 ,  G01N33/587

Abstract: The present invention relates to a composition for target substance detection using a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, a target substance detection system, and a method for obtaining an image of a living body or specimen. As the magnetic nanoparticle of the present invention has a Curie temperature within the temperature range of 0° C. to 41° C., the ferromagnetic and paramagnetic properties of the magnetic nanoparticle may be controlled within a biocompatible temperature range at a temperature at which a biological control agent is not destroyed, and the temperature of the magnetic nanoparticle is adjusted to control the magnetic properties thereof such that the properties of the magnetic nanoparticle may be used only when ferromagnetic properties are required, such as in the case of signal amplification in detecting, separating, and delivering biological control agents. Accordingly, the present invention can provide a biological substance detection system which satisfies both a decrease in non-specific binding and signal amplification using a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, and can be reused after detection.