公开(公告)号：US11419855B2

公开(公告)日：2022-08-23

申请号：US16627058

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin Sugimoto ,  Akito Minamizono

IPC: A61K31/423 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K47/38

Abstract: Provided is a novel technique for improving storage stability of a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and a cellulose species. A pharmaceutical preparation obtained by storing a pharmaceutical composition containing the following components (A) and (B) in a tight package: (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a cellulose species.

公开(公告)号：US11344535B2

公开(公告)日：2022-05-31

申请号：US16627061

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Yuki Kuroiwa ,  Akito Minamizono

IPC: A61K31/423 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent storage stability. The pharmaceutical composition is provided to contain pemafibrate, a salt thereof or a solvate thereof, wherein a pH value of a solution produced by dissolving or dispersing the pharmaceutical composition in water is 7 or more.

公开(公告)号：US11759456B2

公开(公告)日：2023-09-19

申请号：US16627128

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin Sugimoto ,  Akito Minamizono

IPC: A61K31/423 ,  A61K9/20 ,  A61K47/02 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61K31/423 ,  A61K9/20 ,  A61K47/02 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition contains pemafibrate, a salt thereof or a solvate thereof in an amount of 0.017 to 4.2 mass % in terms of a free form of pemafibrate with respect to the total mass of the pharmaceutical composition.

公开(公告)号：US11298340B2

公开(公告)日：2022-04-12

申请号：US16627178

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin Sugimoto ,  Akito Minamizono

IPC: A61K31/423

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.

公开(公告)号：US11730719B2

公开(公告)日：2023-08-22

申请号：US17591108

申请日：2022-02-02

Applicant: KOWA COMPANY, LTD.

Inventor： Shin Sugimoto ,  Akito Minamizono

IPC: A61K31/423

CPC classification number: A61K31/423

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.

公开(公告)号：US11406621B2

公开(公告)日：2022-08-09

申请号：US16627141

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin Sugimoto ,  Akito Minamizono

IPC: A61K31/423 ,  A61K47/26 ,  A61K47/38

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided containing the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a disaccharide species.