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公开(公告)号：US20220340919A1
公开(公告)日：2022-10-27
申请号：US17642987
申请日：2020-09-25
摘要： The present invention relates to novel strategies for gradually decreasing the expression of genes by modifying the promoter sequence. Provided are methods for gradually decreasing the expression level of a nucleic acid molecule of interest in a cell, preferably in a plant cell, comprising the step of introducing at least one modification into a promoter sequence, wherein the modification disrupts a core promoter consensus sequence. Furthermore, the invention also provides methods for producing a cell or an organism, preferably a plant cell or a plant, having a decreased expression level of a nucleic acid molecule of interest. The invention also relates to a cell and an organism, preferably a plant cell and a plant, obtained by a method according to the invention.
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公开(公告)号：US20200229367A1
公开(公告)日：2020-07-23
申请号：US16825490
申请日：2020-03-20
发明人： Christof BOLDUAN , Monika KLOIBER-MAITZ , Markus NIESSEN , Milena OUZUNOVA , Fridtjof WELTMEIER
IPC分类号： A01H1/08 , C07K14/415 , A01H1/06 , A01H6/46 , C12N9/20
摘要： The present invention relates to the provision of technical means such as nucleic acids which, after transcription or after expression in a plant, are suitable for mediating the property of a haploid inductor or for increasing the induction capability of a haploid inductor, as well as methods and uses for the production and identification of non-transgenic and transgenic plant haploid inductors, as well as the improvement of existing plant haploid inductors.
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3.发明申请公开(公告)号：US20210155948A1
公开(公告)日：2021-05-27
申请号：US17040943
申请日：2019-03-26
IPC分类号： C12N15/82 , C12Q1/6897
摘要： The present invention method for increasing the expression level of a nucleic acid molecule of interest in a cell, preferably a plant cell by means of promoter activating nucleic acid sequences, which are able to increase expression of a nucleic acid molecule of interest in a cell or an organism upon site-specific introduction into a recipient promoter controlling the expression of the nucleic acid molecule of interest. The invention also provides methods to identify such promoter activating elements and methods to introduce them into an organism or a cell to specifically increase the expression of a nucleic acid molecule of interest. Furthermore, the invention also relates to the use of the promoter activating elements to increase the expression of a nucleic acid molecule of interest.
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