公开(公告)号：US20230021982A1

公开(公告)日：2023-01-26

申请号：US17822178

申请日：2022-08-25

申请人： KWS SAAT SE & Co. KGaA ,  UNIVERSITY OF ZURICH ,  UNIVERSITY OF BERN

发明人： Bettina KESSEL ,  Milena OUZUNOVA ,  Daniela SCHEUERMANN ,  Beat KELLER ,  Simon KRATTINGER ,  Coraline PRAZ ,  Ping YANG ,  Matthias ERB

IPC分类号： C12N15/82 ,  C12Q1/48 ,  C07K14/415 ,  A01H1/06 ,  A01H1/04 ,  A01H3/04 ,  C12Q1/6827 ,  C12Q1/6869

摘要： The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided. The present invention thus relates to WAKs as master regulators and crucial signaling mediators in plant defense against fungal disease and the regulation and cross-talk mechanisms in the WAK signaling cascade and further gives examples for establishing novel anti-fungal strategies relevant for a series of crop plants.

公开(公告)号：US20200231984A1

公开(公告)日：2020-07-23

申请号：US16640857

申请日：2018-08-22

申请人： KWS SAAT SE & co., KGaA ,  University of Zurich ,  University of Bern

发明人： Bettina KESSEL ,  Milena OUZUNOVA ,  Daniela SCHEUERMANN ,  Beat KELLER ,  Simon KRATTINGER ,  Coraline PRAZ ,  Ping YANG ,  Matthias ERB

IPC分类号： C12N15/82

摘要： The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided. The present invention thus relates to WAKs as master regulators and crucial signaling mediators in plant defense against fungal disease and the regulation and cross-talk mechanisms in the WAK signaling cascade and further gives examples for establishing novel anti-fungal strategies relevant for a series of crop plants.