公开(公告)号：US20230021982A1

公开(公告)日：2023-01-26

申请号：US17822178

申请日：2022-08-25

申请人： KWS SAAT SE & Co. KGaA ,  UNIVERSITY OF ZURICH ,  UNIVERSITY OF BERN

发明人： Bettina KESSEL ,  Milena OUZUNOVA ,  Daniela SCHEUERMANN ,  Beat KELLER ,  Simon KRATTINGER ,  Coraline PRAZ ,  Ping YANG ,  Matthias ERB

IPC分类号： C12N15/82 ,  C12Q1/48 ,  C07K14/415 ,  A01H1/06 ,  A01H1/04 ,  A01H3/04 ,  C12Q1/6827 ,  C12Q1/6869

摘要： The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided. The present invention thus relates to WAKs as master regulators and crucial signaling mediators in plant defense against fungal disease and the regulation and cross-talk mechanisms in the WAK signaling cascade and further gives examples for establishing novel anti-fungal strategies relevant for a series of crop plants.

公开(公告)号：US20200231984A1

公开(公告)日：2020-07-23

申请号：US16640857

申请日：2018-08-22

申请人： KWS SAAT SE & co., KGaA ,  University of Zurich ,  University of Bern

发明人： Bettina KESSEL ,  Milena OUZUNOVA ,  Daniela SCHEUERMANN ,  Beat KELLER ,  Simon KRATTINGER ,  Coraline PRAZ ,  Ping YANG ,  Matthias ERB

IPC分类号： C12N15/82

摘要： The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided. The present invention thus relates to WAKs as master regulators and crucial signaling mediators in plant defense against fungal disease and the regulation and cross-talk mechanisms in the WAK signaling cascade and further gives examples for establishing novel anti-fungal strategies relevant for a series of crop plants.

公开(公告)号：US20230255156A1

公开(公告)日：2023-08-17

申请号：US18015116

申请日：2021-07-14

申请人： KWS SAAT SE & Co. KGaA ,  UNIVERSITY OF ZURICH

发明人： Daniela SCHEUERMANN ,  Milena OUZUNOVA ,  Bettina KESSEL ,  Beat KELLER ,  Ping YANG

IPC分类号： A01H1/04 ,  C12Q1/6895 ,  A01H1/00 ,  A01H6/46 ,  A01H5/10

CPC分类号： A01H1/045 ,  C12Q1/6895 ,  A01H1/1255 ,  A01H6/4684 ,  A01H5/10 ,  C12Q2600/13 ,  C12Q2600/156

摘要： The present invention relates to maize plants having increased pathogen resistance or tolerance, in particular increased resistance or tolerance to pathogens causing Northern Corn Leaf Blight, i.e. Exserohilum turcicum. Such maize plants are characterized by particular molecular markers The invention further relates to methods for identifying such maize plants.

公开(公告)号：US20210071194A1

公开(公告)日：2021-03-11

申请号：US16640973

申请日：2018-08-22

申请人： KWS SAAT SE & Co. KGaA ,  University of Zurich

发明人： Bettina KESSEL ,  Milena OUZUNOVA ,  Thomas PRESTERL ,  Daniela SCHEUERMANN ,  Gerhard HERREN ,  Beat KELLER ,  Simon KRATTINGER ,  Thomas WICKER ,  Ping YANG

IPC分类号： C12N15/82 ,  C12Q1/6869 ,  C12Q1/6827

摘要： The present invention relates to a nucleic acid molecule encoding a polypeptide conferring resistance to a plant against a fungal pathogen, such as Helminthosporium turcicum. The present invention further relates to a plant (or part thereof) comprising the nucleic acid molecule, and methods involving the nucleic acid molecule.

公开(公告)号：US20240271155A1

公开(公告)日：2024-08-15

申请号：US18569441

申请日：2022-06-22

申请人： KWS SAAT SE & Co. KGaA

发明人： Daniela SCHEUERMANN ,  Thomas PRESTERL ,  Bettina KESSEL ,  Dietmar Jürgen STAHL ,  Daniel Fabian STIRNWEIS ,  Jan BETTGENHÄUSER

IPC分类号： C12N15/82 ,  A01H1/00 ,  A01H6/46 ,  C12Q1/6895

CPC分类号： C12N15/8282 ,  A01H1/1255 ,  A01H6/4684 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156

摘要： The present invention relates to maize plants having increased pathogen resistance or tolerance, in particular increased resistance or tolerance to pathogens causing Northern Corn Leaf Blight, i.e. Exserohilum turcicum. Such maize plants can be characterized as having a particular QTL allele comprising one or more resistance gene, or particular molecular markers The invention further relates to methods for generating such maize plants, as well as methods for identifying such maize plants.

公开(公告)号：US20230054527A1

公开(公告)日：2023-02-23

申请号：US17783997

申请日：2020-12-18

申请人： KWS SAAT SE & Co. KGaA

发明人： Daniela SCHEUERMANN ,  Thomas PRESTERL ,  Bettina KESSEL ,  Dietmar STAHL ,  Daniel Fabian STIRNWEIS

IPC分类号： C12Q1/6895 ,  A01H6/46

摘要： The present invention relates to maize plants having increased pathogen resistance or tolerance, in particular increased resistance or tolerance to pathogens causing Northern Corn Leaf Blight, i.e. Exserohilum turcicum. Such maize plants can be characterized as having a particular QTL allele comprising one or more resistance gene, or particular molecular markers in chromosome 4 based on donor line H102. The invention further relates to methods for generating such maize plants, as well as methods for identifying such maize plants.

公开(公告)号：US20210137040A1

公开(公告)日：2021-05-13

申请号：US17123991

申请日：2020-12-16

申请人： KWS SAAT SE & CO. KGAA ,  UNIVERSITÄT ZÜRICH

发明人： Milena OUZUNOVA ,  Daniela SCHEUERMANN ,  Beat KELLER ,  Simon KRATTINGER ,  Thomas WICKER ,  Gerhard HERREN ,  Severine HURNI ,  Bettina KESSEL ,  Thomas PRESTERL ,  Carsten KNAAK

IPC分类号： A01H1/04 ,  C12Q1/6895 ,  C07K14/415 ,  A01H5/00 ,  C12N15/82

摘要： The present invention provides an improved Helminthosporium turcicum-resistant plant, in particular a maize plant which comprises a polynucleotide with one or more resistance-conferring genes, for example on a truncated chromosome fragment from the accession Pepitilla, as well as a cell, a tissue, a part, grain and seeds thereof, an isolated polynucleotide which comprises one or more resistance-conferring genes against Helminthosporium turcicum, a vector, a transgenic plant cell and a transgenic plant containing this polynucleotide. Furthermore, the invention encompasses suitable markers and their use in introducing resistance or the transgene into a plant, as well as the identification of improved maize plants which comprise a truncated chromosome fragment.

公开(公告)号：US20230313220A1

公开(公告)日：2023-10-05

申请号：US18154191

申请日：2023-01-13

申请人： KWS SAAT SE & Co. KGaA

发明人： Aurelie BAK ,  Dietmar STAHL ,  Daniel STIRNWEIS ,  Daniela SCHEUERMANN ,  Bettina KESSEL

IPC分类号： C12N15/82 ,  C12N9/22 ,  A01H6/46 ,  A01H6/20

CPC分类号： C12N15/8279 ,  A01H6/204 ,  A01H6/4684 ,  C12N9/22 ,  C12N15/8218 ,  C12N2310/20

摘要： The present application provides a new technology to confer or enhance insect resistance and, optionally also resistance to fungal pathogens in plants. In particular, the present invention provides a method for conferring or increasing resistance or tolerance to insect and optionally also to fungal pathogens in maize and oil seed rape (OSR) by targeting the endogenous Lox3 gene. By introducing either a gene silencing construct, a genome editing system or a genome modification, which leads to a targeted knock-down or knock-out of the Lox3 gene endogenous to the plant, a new or increased resistance to insect and, optionally fungal pathogens can be created.