公开(公告)号：US09452977B2

公开(公告)日：2016-09-27

申请号：US14576867

申请日：2014-12-19

申请人： KYORIN PHARMACEUTICAL CO., LTD. ,  TEIJIN PHARMA LIMITED

发明人： Yasumichi Fukuda ,  Yoshikazu Asahina ,  Masanori Takadoi ,  Masanori Yamamoto

IPC分类号： C07C59/46 ,  C07C309/77 ,  C07D213/75 ,  C07D231/38 ,  C07D241/20 ,  C07D261/14 ,  C07D277/20 ,  C07D277/44 ,  C07D277/82 ,  C07D285/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12 ,  C07D513/04 ,  C07F9/54 ,  C07F9/6509 ,  C07F9/6539

CPC分类号： C07C309/77 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/75 ,  C07D231/38 ,  C07D241/20 ,  C07D261/14 ,  C07D277/20 ,  C07D277/44 ,  C07D277/82 ,  C07D285/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12 ,  C07D513/04 ,  C07F9/5442 ,  C07F9/650952 ,  C07F9/6539

摘要： A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of diabetes, obesity, and the like. The compound is represented by the general formula (1): (wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1 to C6 alkyl group, a C1 to C6 alkoxy group, a C1 to C6 alkylsulfanyl group, a C1 to C6 alkylsulfinyl group, a C1 to C6 alkylsulfonyl group, or a C1 to C6 alkoxy-C1 to C6 alkylsulfonyl group, and A is a substituted or unsubstituted heteroaryl group).