公开(公告)号：US11332455B2

公开(公告)日：2022-05-17

申请号：US17034604

申请日：2020-09-28

Applicant: KYOWA KIRIN CO., LTD.

Inventor： Tomohiro Danjo ,  Katsuaki Fujiwara ,  Tomoyuki Nishikawa ,  Takahiro Nakajima ,  Nobumasa Otsubo ,  Toshihiro Seike

IPC: C07D311/68 ,  C07D401/04 ,  C07D405/12 ,  C07D311/74 ,  A61K31/5377 ,  A61K31/353 ,  C07D215/38 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/47 ,  C07D213/74 ,  C07D213/75 ,  C07D215/24 ,  C07D401/12

Abstract: The present invention provides an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like represented by the following formula (I): [wherein, “A” represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents —O—, —S—, —SO2—, —NRX1— (wherein, RX1 represents hydrogen atom or lower alkyl), —CHRX2— (wherein, RX2 represents hydrogen atom or hydroxy), —CH═CH—, —CO— or —NH—CO—, and n1 and n2 are the same or different, and each represents 0 or 1].

公开(公告)号：US10787428B2

公开(公告)日：2020-09-29

申请号：US16065937

申请日：2016-12-22

Applicant: KYOWA KIRIN CO., LTD.

Inventor： Tomohiro Danjo ,  Katsuaki Fujiwara ,  Tomoyuki Nishikawa ,  Takahiro Nakajima ,  Nobumasa Otsubo ,  Toshihiro Seike

IPC: C07D213/74 ,  C07D311/68 ,  C07D401/04 ,  C07D405/12 ,  C07D311/74 ,  A61K31/5377 ,  A61K31/353 ,  C07D215/38 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/47 ,  C07D213/75 ,  C07D215/24 ,  C07D401/12

Abstract: The present invention provides an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like represented by the following formula (I): [wherein, “A” represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents —O—, —S—, —SO2—, —NRX1— (wherein, RX1 represents hydrogen atom or lower alkyl), —CHRX2— (wherein, RX2 represents hydrogen atom or hydroxy), —CH═CH—, —CO— or —NH—CO—, and n1 and n2 are the same or different, and each represents 0 or 1].

公开(公告)号：US11447471B2

公开(公告)日：2022-09-20

申请号：US16625446

申请日：2018-06-22

Applicant: KYOWA KIRIN CO., LTD.

Inventor： Tomohiro Danjo ,  Hiroki Yamada ,  Takahiro Nakajima

IPC: A61P35/00 ,  C07D263/56 ,  C07D263/57 ,  C07D267/14 ,  C07D277/64 ,  C07D307/83 ,  C07D307/86 ,  C07D313/08 ,  C07D405/12 ,  C07D213/63 ,  C07D213/643 ,  C07D213/75 ,  C07D215/227 ,  C07D215/233 ,  C07D215/26 ,  C07D215/38 ,  C07D215/40 ,  C07D217/02 ,  C07D311/58 ,  C07D311/68 ,  C07D333/66 ,  C07D401/04 ,  C07D401/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/052

Abstract: An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like: [wherein, “A” represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents —O—, —S—, —SO2—, —NRX1— (wherein, RX1 represents hydrogen atom or lower alkyl), —CHRX2— (wherein, RX2 represents hydrogen atom or hydroxy), —CH═CH—, −CO— or —NH—CO—, and n1 and n2 are the same or different, and each represents 0 or 1].