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公开(公告)号：US20190249222A1
公开(公告)日：2019-08-15
申请号：US16319853
申请日：2017-07-28
发明人： Haruyo Soya , Yuki Katayama , Noriyuki Ogawa
IPC分类号： C12Q1/28
摘要： A method is provided for measuring glycated hemoglobin in a hemoglobin-containing sample which comprises reacting glycated hemoglobin in the hemoglobin-containing sample with an enzyme that catalyzes a reaction of oxidizing the glycated hemoglobin to generate hydrogen peroxide, in the presence of at least one anionic surfactant selected from the group consisting of N-acyl taurine in which a hydrogen atom of the amino group may be substituted with a substituent, alkyl sulfoacetic acid, polyoxyethylene alkyl ether acetic acid, N-acyl amino acid in which a hydrogen atom of the amino group may be substituted with a substituent, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene polycyclic phenyl ether phosphoric acid, alkyl phosphoric acid, and salts thereof, to generate hydrogen peroxide, and measuring the generated hydrogen peroxide.
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公开(公告)号：US20190177548A1
公开(公告)日：2019-06-13
申请号：US16320343
申请日：2017-07-28
发明人： Haruyo Soya , Yuki Katayama
摘要： The present invention provides a method for preserving a leuco chromogen-containing aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; a method for stabilizing a leuco chromogen in an aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; and a liquid reagent comprising a leuco chromogen and at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound.
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公开(公告)号：US20150004635A1
公开(公告)日：2015-01-01
申请号：US14372766
申请日：2013-02-06
发明人： Haruyo Soya
IPC分类号： C12Q1/54
CPC分类号： C12Q1/54 , C12Q1/26 , C12Q1/37 , C12Q2523/113
摘要： Provided is a method for suppressing an effect of ascorbic acid on a measurement of glycated hemoglobin in a glycated hemoglobin-containing sample. The method of the present invention is a method for suppressing an effect of ascorbic acid on the measurement of glycated hemoglobin in a glycated hemoglobin-containing sample, comprising reacting the glycated hemoglobin-containing sample with a proteolytic enzyme, reacting a generated glycated peptide with a glycated peptide oxidase, and then measuring a generated hydrogen peroxide, wherein the reaction of the glycated peptide with the glycated peptide oxidase is performed in the presence of a halogen oxide and a substance selected from the group consisting of a substance represented by formula (I), wherein R1 represents substituted or unsubstituted alkyl and a substance represented by the general formula (II), wherein R2 represents substituted or unsubstituted alkyl; and represents a single bond or a double bond.
摘要翻译： 本发明提供了抑制含糖血红蛋白的样品中抗坏血酸对糖化血红蛋白测定的影响的方法。 本发明的方法是抑制抗坏血酸对糖化血红蛋白含量样品中糖化血红蛋白测定的影响的方法，其包括使含糖基血红蛋白的样品与蛋白水解酶反应，使产生的糖化肽与 糖化肽氧化酶，然后测量产生的过氧化氢，其中糖化肽与糖化肽氧化酶的反应在卤素氧化物和选自由式（I）表示的物质的存在下进行， 其中R1表示取代或未取代的烷基和由通式（II）表示的物质，其中R2表示取代或未取代的烷基; 并且表示单键或双键。
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