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公开(公告)号：US12102666B2
公开(公告)日：2024-10-01
申请号：US17281952
申请日：2020-07-02
Inventor： Jung Min Kim , Jong Sook Jin , Shukho Kim
IPC: A61K38/47 , A01N63/50 , A23C9/152 , A23K20/147 , A23K20/195 , A23L3/3463 , A23L3/3526 , A23L33/10 , A23L33/175 , A61P31/04 , A01P1/00
CPC classification number: A61K38/47 , A01N63/50 , A23C9/1526 , A23K20/147 , A23K20/195 , A23L3/34635 , A23L3/3526 , A23L33/127 , A23L33/175 , A61P31/04 , A01P1/00 , A23V2002/00
Abstract: The present invention relates to a method of using a recombinant antibacterial protein, termed Ablysin, for effectively killing multidrug-resistant pathogenic bacteria. The recombinant protein Ablysin is administered to prevent or treat infectious diseases caused by the antibiotic-resistant bacteria Acinetobacter baumannii. Ablysin can be widely used in antibiotics, disinfectants, food additives, feed additives, and the like. In particular, the Ablysin protein uses peptidoglycan, a component of the cell wall of bacteria, as a substrate and exhibits bacterial killing ability due to peptidoglycan degradation. The Ablysin of the present invention can be applied in the pharmaceutical industry, food industry, biotechnology, or similar industries, as the protein effectively kills bacteria at a desired place or in a target substance without problems of resistance that occurs in other antimicrobial agents.
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公开(公告)号：US12220448B2
公开(公告)日：2025-02-11
申请号：US17262184
申请日：2019-08-28
Inventor： Jung Min Kim , Jong Sook Jin , Shukho Kim
Abstract: The invention relates to a method of preventing or treating pathogenic bacterial infectious diseases by providing a pharmaceutical composition comprising a LysSAP26 protein, wherein the LysSAP26 protein is a recombinant protein composed of an amino acid sequence derived from the bacteriophage genome and has the amino acid sequence set forth in SEQ ID NO: 1 as an active ingredient, and administering the pharmaceutical composition to a subject.
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