公开(公告)号：US20160237404A1

公开(公告)日：2016-08-18

申请号：US15025946

申请日：2014-09-23

Applicant: Kadimastem Ltd.

Inventor： Michal IZRAEL ,  Michel REVEL ,  Arik HASSON ,  Kfir MOLAKANDOV ,  Judith CHEBATH

IPC: C12N5/079 ,  G01N33/50 ,  A61K35/30

CPC classification number: C12N5/0622 ,  A61K35/30 ,  C12N5/0619 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/385 ,  C12N2502/081 ,  C12N2502/086 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2506/02 ,  C12N2533/32 ,  C12N2533/52 ,  C12N2533/90 ,  G01N33/5058 ,  G01N33/5073 ,  G01N2510/00

Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.

Abstract translation: 本发明公开了使用离体分化多能干细胞（PSC）鉴定影响人星形胶质细胞功能的试剂的方法。 此外，还公开了人类祖细胞或人星形胶质细胞在人类受试者中用于治疗肌萎缩性侧索硬化症（ALS）的用途。