公开(公告)号：US20210054334A1

公开(公告)日：2021-02-25

申请号：US16564893

申请日：2019-09-09

Applicant: Kadimastem Ltd.

Inventor： Michal Izrael ,  Michel Revel ,  Arik Hasson ,  Kfir Molakandov ,  Judith Chebath

IPC: C12N5/079 ,  A61K35/30 ,  G01N33/50 ,  C12N5/0793

Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.

公开(公告)号：US20180230427A1

公开(公告)日：2018-08-16

申请号：US15863016

申请日：2018-01-05

Applicant: Kadimastem Ltd.

Inventor： Michal Izrael ,  Michel Revel ,  Arik Hasson ,  Kfir Molakandov ,  Judith Chebath

IPC: C12N5/079 ,  C12N5/0793 ,  G01N33/50 ,  A61K35/30

CPC classification number: C12N5/0622 ,  A61K35/30 ,  C12N5/0619 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/385 ,  C12N2502/081 ,  C12N2502/086 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2506/02 ,  C12N2533/32 ,  C12N2533/52 ,  C12N2533/90 ,  G01N33/5058 ,  G01N33/5073 ,  G01N2510/00

Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.

公开(公告)号：US20200003757A1

公开(公告)日：2020-01-02

申请号：US16511985

申请日：2019-07-15

Applicant: KADIMASTEM, LTD.

Inventor： Michel Revel ,  Judith Chebath ,  Arye Hasson ,  Michal Izrael ,  Rosalia Kaufman

IPC: G01N33/50

Abstract: The present invention discloses a method of identifying agents that affect maturation and survival of oligodendrocytes or myelination of neuronal cells using ex-vivo differentiated embryonic stem cells.

公开(公告)号：US20170095512A1

公开(公告)日：2017-04-06

申请号：US15315934

申请日：2015-06-02

Applicant: KADIMASTEM LTD.

Inventor： Michal Izrael ,  Michel Revel ,  Arik Hasson ,  Judith Chebath

IPC: A61K35/30 ,  C12N5/079 ,  A61K31/519

CPC classification number: A61K35/30 ,  A61K31/4418 ,  A61K31/519 ,  A61K38/18 ,  C12N5/0622 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2533/32 ,  C12N2533/90

Abstract: The present invention disclosed methods of inducing maturation of oligodendrocyte cells. A method of inducing myelination in a patient suffering from demyelination is also disclosed