公开(公告)号：US20240360085A1

公开(公告)日：2024-10-31

申请号：US18672406

申请日：2024-05-23

申请人： Kadmon Corporation, LLC

发明人： Kevin G. Liu ,  Kellen Olszewski ,  Ji-In Kim ,  Masha V. Poyurovsky ,  Koi Morris ,  Xuemei Yu ,  Christophe Lamarque

IPC分类号： C07D239/42 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00

CPC分类号： C07D239/42 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00

摘要： This invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUT3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.

公开(公告)号：US12030857B2

公开(公告)日：2024-07-09

申请号：US16973941

申请日：2019-06-25

申请人： Kadmon Corporation, LLC

发明人： Kevin G. Liu ,  Kellen L. Olszewski ,  Ji-In Kim ,  Masha V. Poyurovsky ,  Koi Morris ,  Xuemei Yu ,  Christophe Lamarque

IPC分类号： C07D239/42 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00

CPC分类号： C07D239/42 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00

摘要： This invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUTS3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.