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公开(公告)号：US20100129293A1
公开(公告)日：2010-05-27
申请号：US12693749
申请日：2010-01-26
IPC分类号： A61K49/00 , C07D403/02
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US07025949B2
公开(公告)日：2006-04-11
申请号：US09850660
申请日：2001-05-07
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
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公开(公告)号：US20060165598A1
公开(公告)日：2006-07-27
申请号：US11387200
申请日：2006-03-22
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US20050169844A1
公开(公告)日：2005-08-04
申请号：US11093082
申请日：2005-03-29
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US07445767B2
公开(公告)日：2008-11-04
申请号：US11387200
申请日：2006-03-22
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US06926885B2
公开(公告)日：2005-08-09
申请号：US10180272
申请日：2002-06-26
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10 , A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US06913743B2
公开(公告)日：2005-07-05
申请号：US10368997
申请日：2003-02-19
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10 , A61K39/395
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
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公开(公告)号：US20050106106A1
公开(公告)日：2005-05-19
申请号：US11013596
申请日：2004-12-16
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US07655217B2
公开(公告)日：2010-02-02
申请号：US11387367
申请日：2006-03-22
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为用于荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US6083485A
公开(公告)日：2000-07-04
申请号：US849369
申请日：1997-11-07
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10 , G01N31/00 , G01N33/48
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： PCT No.PCT / DE95 / 01465 Sec。 371日期：1997年11月7日 102（e）日期1997年11月7日PCT提交1995年10月10日PCT公布。 公开号WO96 / 17628 日期1996年6月13日本发明涉及一种使用水溶性染料及其生物分子加合物的近红外辐射（NIR辐射）的体内诊断方法，其具有特定的光物理和药物化学性质，作为造影剂 NIR系列中的荧光和透照诊断，新染料和含有这些染料的药物。
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