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公开(公告)号：US07025949B2
公开(公告)日：2006-04-11
申请号：US09850660
申请日：2001-05-07
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
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公开(公告)号：US20060165598A1
公开(公告)日：2006-07-27
申请号：US11387200
申请日：2006-03-22
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US20050169844A1
公开(公告)日：2005-08-04
申请号：US11093082
申请日：2005-03-29
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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公开(公告)号：US20060165599A1
公开(公告)日：2006-07-27
申请号：US11387367
申请日：2006-03-22
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
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公开(公告)号：US20050106106A1
公开(公告)日：2005-05-19
申请号：US11013596
申请日：2004-12-16
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： 本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。
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6.发明授权Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy 有权酸不稳定和酶分裂的染料化合物，用于近红外光诊断和治疗公开(公告)号：US06534041B1
公开(公告)日：2003-03-18
申请号：US09403418
申请日：2000-05-01
申请人： Kai Licha , Bjorn Riefke , Wolfhard Semmler , Wolfgang Wrasidlo
发明人： Kai Licha , Bjorn Riefke , Wolfhard Semmler , Wolfgang Wrasidlo
IPC分类号： A61B1000
CPC分类号： A61K49/0032 , A61K49/0052 , A61K49/0058 , C07H15/252 , C09B23/086 , C09B69/10 , G01N33/574 , G01N33/582 , G01N33/583
摘要： The invention relates to acid-labile and enzymatically divisible compounds for in-vivo and in-vitro diagnosis by means of near infrared radiation (NIR-radiation), the use of said compounds as optic diagnostic and therapeutic agents, and the diagnostic agents containing said compounds.
摘要翻译： 本发明涉及用于通过近红外辐射（NIR辐射）进行体内和体外诊断的酸不稳定和可酶分解的化合物，所述化合物作为光学诊断和治疗剂的用途，以及含有所述 化合物。
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7.发明授权Optical diagnostic agents for diagnosis of neurodegenerative diseases by means of near infrared radiation (NIR radiation) 失效用于通过近红外辐射（NIR辐射）诊断神经变性疾病的光学诊断剂公开(公告)号：US06329531B1
公开(公告)日：2001-12-11
申请号：US09308177
申请日：1999-11-18
申请人： Jonathan Turner , Thomas Dyrks , Wolfhard Semmler , Kai Licha , Bjorn Riefke
发明人： Jonathan Turner , Thomas Dyrks , Wolfhard Semmler , Kai Licha , Bjorn Riefke
IPC分类号： G01N3351
CPC分类号： A61K49/0052 , A61K49/0032 , A61K49/0054 , A61K49/0056 , C07H15/26 , C08B37/0075 , C09B23/086 , C09B56/16 , G01N33/52 , G01N33/6896 , G01N2800/28
摘要： The invention relates to compounds of formula (I): Fm(—A1)(—Bn)(—Wo) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600-1200 nm; A is a &bgr;-amyloid plaque binding biomolecule; B is a &bgr;-amyloid plaque binding colorant; and W is a &bgr;-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo an din vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a constrasting agent in fluoresecence and transillumination diagnosis in the NIR range. Diagnostic agents containing said componenets are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：Fm（-A1）（-Bn）（-Wo）其中F是最大吸收值范围为600-1200nm的着色剂 - 信号分子; A是β-淀粉样蛋白斑块结合生物分子; B是β-淀粉样斑块结合着色剂; W是β-淀粉样蛋白斑结合亲水性低分子结构元件。 本发明还描述了这些化合物在体内通过近红外辐射（NIR辐射）作为NIR范围内荧光和透照诊断中的补体的体内诊断神经变性疾病如阿尔茨海默病的体外诊断。 还公开了含有所述组分的诊断剂。
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公开(公告)号：US6083485A
公开(公告)日：2000-07-04
申请号：US849369
申请日：1997-11-07
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10 , G01N31/00 , G01N33/48
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： PCT No.PCT / DE95 / 01465 Sec。 371日期：1997年11月7日 102（e）日期1997年11月7日PCT提交1995年10月10日PCT公布。 公开号WO96 / 17628 日期1996年6月13日本发明涉及一种使用水溶性染料及其生物分子加合物的近红外辐射（NIR辐射）的体内诊断方法，其具有特定的光物理和药物化学性质，作为造影剂 NIR系列中的荧光和透照诊断，新染料和含有这些染料的药物。
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