-
公开(公告)号：US08389520B2
公开(公告)日：2013-03-05
申请号：US12447192
申请日：2007-10-12
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
-
2.发明申请SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS 有权取代的二氢吡咯烷酮及其作为HIF-PROLYL-4-羟基酶抑制剂的用途公开(公告)号：US20120264704A1
公开(公告)日：2012-10-18
申请号：US12447201
申请日：2007-10-26
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/506 , C07D417/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/517 , A61K31/501 , A61K31/4709 , A61K31/497 , A61K31/55 , A61P7/10 , A61K31/616 , A61P31/04 , A61P35/00 , A61K31/7048 , A61P9/00 , A61P7/06 , A61P13/12 , C07D471/04 , A61K31/498 , A61K31/714 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
公开(公告)号：US08609698B2
公开(公告)日：2013-12-17
申请号：US12447207
申请日：2007-10-16
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D401/14
摘要： The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代二吡啶基二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
4.发明授权Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors 有权取代的二氢吡唑酮及其作为HIF-脯氨酰基-4-羟化酶抑制剂的用途公开(公告)号：US08524699B2
公开(公告)日：2013-09-03
申请号：US12447201
申请日：2007-10-26
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/501 , A61K31/4965 , A61K31/4725 , A61K31/4427 , A61K31/55 , C07D413/14 , C07D487/12 , C07D403/14 , C07D401/14 , C07D417/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
公开(公告)号：US20100093803A1
公开(公告)日：2010-04-15
申请号：US12447207
申请日：2007-10-16
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
IPC分类号： A61K31/444 , C07D401/14
CPC分类号： C07D401/14
摘要： The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代二吡啶基二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
6.发明授权Substituted dihydropyrazolones for treating cardiovascular and hematological diseases 有权取代二氢吡唑酮用于治疗心血管和血液疾病公开(公告)号：US08653111B2
公开(公告)日：2014-02-18
申请号：US13356256
申请日：2012-01-23
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
7.发明申请SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES 有权用于治疗心血管和血液病的替代二氢吡咯烷酮公开(公告)号：US20100305085A1
公开(公告)日：2010-12-02
申请号：US12447192
申请日：2007-10-12
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/397 , C07D401/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/4545 , C07D403/14 , A61K31/506 , A61P9/00 , A61P13/12
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to dihydropyrazolon-derivatives of formula (I), to methods for their production, to their use for treating and/or for preventing diseases and their use for producing medicaments for treating and/or for preventing diseases, in particular cardiovascular and haematological diseases, kidney diseases and for promoting the healing of wounds.
摘要翻译： 本发明涉及式（I）的二氢吡唑酮衍生物，其生产方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是心血管和血液学 疾病，肾脏疾病和促进伤口愈合。
-
8.发明授权4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases 有权4-（吡啶-3-基）-2（吡啶-2-基）-1,2-二氢-3H-吡唑-3-酮衍生物作为特异性HIF-裂解-4-羟化酶抑制剂用于治疗心血管和血液病公开(公告)号：US09085572B2
公开(公告)日：2015-07-21
申请号：US13594622
申请日：2012-08-24
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： C07D401/14 , A61K31/4439 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
公开(公告)号：US08252817B2
公开(公告)日：2012-08-28
申请号：US11919478
申请日：2006-04-15
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
公开(公告)号：US20100035906A1
公开(公告)日：2010-02-11
申请号：US11919478
申请日：2006-04-15
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： A61K31/506 , C07D401/14 , A61P9/00 , A61P13/12 , A61K31/444
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.041 秒)
