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公开(公告)号：US08389520B2
公开(公告)日：2013-03-05
申请号：US12447192
申请日：2007-10-12
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
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2.发明申请SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS 有权取代的二氢吡咯烷酮及其作为HIF-PROLYL-4-羟基酶抑制剂的用途公开(公告)号：US20120264704A1
公开(公告)日：2012-10-18
申请号：US12447201
申请日：2007-10-26
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/506 , C07D417/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/517 , A61K31/501 , A61K31/4709 , A61K31/497 , A61K31/55 , A61P7/10 , A61K31/616 , A61P31/04 , A61P35/00 , A61K31/7048 , A61P9/00 , A61P7/06 , A61P13/12 , C07D471/04 , A61K31/498 , A61K31/714 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US20120028950A1
公开(公告)日：2012-02-02
申请号：US13103305
申请日：2011-05-09
申请人： Michael HÄRTER , Hartmut BECK , Susanne GRESCHAT , Peter ELLINGHAUS , Kerstin BERHÖRSTER , Joachim SCHUHMACHER
发明人： Michael HÄRTER , Hartmut BECK , Susanne GRESCHAT , Peter ELLINGHAUS , Kerstin BERHÖRSTER , Joachim SCHUHMACHER
IPC分类号： A61K31/4245 , A61K31/454 , A61P35/00 , A61P9/10 , A61P9/04 , A61P9/06 , A61P9/12 , A61P11/00 , A61P13/12 , A61P17/06 , A61P27/02 , A61P29/00 , A61P25/00 , A61P7/00 , C07D413/14
CPC分类号： A61K31/454 , A61K31/4245 , A61K45/06 , C07D413/14
摘要： The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及新的取代的1- [3-（杂环基）苄基] -1H-吡唑衍生物，其制备方法，其用于治疗和/或预防疾病及其用于生产用于治疗的药物的用途 和/或预防疾病，特别是用于治疗和/或预防过度增生和血管生成疾病以及由代谢适应缺氧状态引起的疾病。 这样的治疗可以以单一疗法的形式进行，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US20090203582A1
公开(公告)日：2009-08-13
申请号：US12249888
申请日：2008-10-10
申请人： Franz VON NUSSBAUM , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
发明人： Franz VON NUSSBAUM , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
摘要： The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及溶血酶蛋白酰胺及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。
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5.发明授权Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管生成相关的疾病的杂芳基取代的吡唑衍生物公开(公告)号：US08796253B2
公开(公告)日：2014-08-05
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/04
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译： 本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。
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公开(公告)号：US08324222B2
公开(公告)日：2012-12-04
申请号：US12086784
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： C07D491/04 , A61K31/519 , A61P9/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新的循环取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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公开(公告)号：US08183246B2
公开(公告)日：2012-05-22
申请号：US12086783
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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公开(公告)号：US08076285B2
公开(公告)日：2011-12-13
申请号：US12249888
申请日：2008-10-10
申请人： Franz Von Nussbaum , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
发明人： Franz Von Nussbaum , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
摘要： The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及溶血酶蛋白酰胺及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。
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公开(公告)号：US20110166163A1
公开(公告)日：2011-07-07
申请号：US12664748
申请日：2008-06-03
申请人： Thomas Lampe , Raimund Kast , Mario Jeske , Friederike Stoll , Joachim Schuhmacher , Eva-Maria Becker , Hartmut Beck
发明人： Thomas Lampe , Raimund Kast , Mario Jeske , Friederike Stoll , Joachim Schuhmacher , Eva-Maria Becker , Hartmut Beck
IPC分类号： A61K31/519 , C07D491/048 , A61P9/12 , A61P9/00 , A61P7/02 , A61P9/10
CPC分类号： C07D491/048
摘要： The present application relates to novel substituted furopyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新的取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备药物的用途，所述药物用于治疗和/或预防疾病，特别是用于治疗和/ /或预防心血管疾病。
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公开(公告)号：US20100093803A1
公开(公告)日：2010-04-15
申请号：US12447207
申请日：2007-10-16
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
IPC分类号： A61K31/444 , C07D401/14
CPC分类号： C07D401/14
摘要： The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代二吡啶基二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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