公开(公告)号：US20100183658A1

公开(公告)日：2010-07-22

申请号：US12593659

申请日：2008-03-28

申请人： Kai W. Wucherpfennig ,  Melissa Joy Call ,  Xuechao Xing ,  Ross L. Stein ,  Gregory D. Cuny

发明人： Kai W. Wucherpfennig ,  Melissa Joy Call ,  Xuechao Xing ,  Ross L. Stein ,  Gregory D. Cuny

IPC分类号： A61K39/385 ,  A61K31/41 ,  A61K31/47 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/427 ,  A61K31/506 ,  A61K31/497 ,  A61K31/405 ,  A61K38/02 ,  A61P37/06

CPC分类号： A61K31/405 ,  C07D209/42 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D417/12 ,  Y02A50/387 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/471 ,  Y02A50/483

摘要： The invention provides classes of novel compounds that accelerate peptide loading to DR in the absence of DM and related pharmaceutical compositions. The invention also provides conjugates of these compounds with peptides, antigens or other MHC-based therapeutics, including peptides that self-catalyze their loading onto MHC Class II molecules. Methods are provided for modulating an immune response in a subject. Also disclosed are methods of using the novel compounds, e.g., in combination with MHC-based therapeutics, for the treatment of autoimmune diseases and for the manufacture of medicaments. Methods of improving loading of viral peptides and tumor peptides for enhancing the CD4 T cell response following vaccination against viruses or tumors, and related vaccines, are also provided.

摘要翻译： 本发明提供了在不存在DM和相关药物组合物的情况下加速肽向DR加载的新类化合物。 本发明还提供了这些化合物与肽，抗原或其他基于MHC的治疗剂的缀合物，包括自身催化其在MHC II类分子上的载体的肽。 提供用于调节受试者的免疫应答的方法。 还公开了使用新化合物的方法，例如与基于MHC的治疗剂组合用于治疗自身免疫性疾病和用于制备药物。 还提供了改善病毒肽和肿瘤肽负荷以增强针对病毒或肿瘤疫苗接种后的CD4T细胞应答的方法以及相关疫苗。