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公开(公告)号：US20100183658A1
公开(公告)日：2010-07-22
申请号：US12593659
申请日：2008-03-28
IPC分类号： A61K39/385 , A61K31/41 , A61K31/47 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/506 , A61K31/497 , A61K31/405 , A61K38/02 , A61P37/06
CPC分类号： A61K31/405 , C07D209/42 , C07D401/12 , C07D403/04 , C07D403/12 , C07D417/12 , Y02A50/387 , Y02A50/463 , Y02A50/465 , Y02A50/471 , Y02A50/483
摘要： The invention provides classes of novel compounds that accelerate peptide loading to DR in the absence of DM and related pharmaceutical compositions. The invention also provides conjugates of these compounds with peptides, antigens or other MHC-based therapeutics, including peptides that self-catalyze their loading onto MHC Class II molecules. Methods are provided for modulating an immune response in a subject. Also disclosed are methods of using the novel compounds, e.g., in combination with MHC-based therapeutics, for the treatment of autoimmune diseases and for the manufacture of medicaments. Methods of improving loading of viral peptides and tumor peptides for enhancing the CD4 T cell response following vaccination against viruses or tumors, and related vaccines, are also provided.
摘要翻译： 本发明提供了在不存在DM和相关药物组合物的情况下加速肽向DR加载的新类化合物。 本发明还提供了这些化合物与肽，抗原或其他基于MHC的治疗剂的缀合物，包括自身催化其在MHC II类分子上的载体的肽。 提供用于调节受试者的免疫应答的方法。 还公开了使用新化合物的方法，例如与基于MHC的治疗剂组合用于治疗自身免疫性疾病和用于制备药物。 还提供了改善病毒肽和肿瘤肽负荷以增强针对病毒或肿瘤疫苗接种后的CD4T细胞应答的方法以及相关疫苗。
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2.发明授权
公开(公告)号：US5874531A
公开(公告)日：1999-02-23
申请号：US400796
申请日：1995-03-07
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/104 , A61K39/145 , A61K39/15 , A61K39/235 , A61K39/245 , A61P25/00 , A61P37/00 , C07K7/08 , C07K14/11 , C07K14/14 , C07K14/47 , C07K14/74 , G01N33/564 , A61K38/04
CPC分类号： A61K39/0008 , C07K14/005 , C07K14/4713 , C07K14/70539 , C07K7/08 , G01N33/564 , G01N33/6878 , A61K39/00 , C12N2710/10322 , C12N2710/16222 , C12N2710/16622 , C12N2710/20022 , C12N2720/12022 , C12N2760/16122 , G01N2800/285
摘要： The present invention provides isolated peptides relating to the autoimmune diseases pemphigus vulgaris and multiple sclerosis. The peptides relating to pemphigus vulgaris are self epitopes and those relating to multiple sclerosis are foreign antigens derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharamaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharamaceutical preparations and methods of use for these epitopes are also provided.
摘要翻译： 本发明提供了与自身免疫疾病寻常型天疱疮和多发性硬化相关的分离的肽。 与寻常型天疱疮有关的肽是自身表位，与多发性硬化相关的肽是来自人类病原体的外来抗原，其涉及病因和疾病的缓解。 提供了用于容忍和/或免疫个体的药物制剂以及与其有关的方法。 提供了用于鉴定涉及人自身免疫疾病的其他自身和非自身表位的方法和类似的药物制剂，并且还提供了这些表位的使用方法。
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3.发明授权Compositions and methods for the generation of MHC class II compounds by peptide exchange 有权通过肽交换产生MHC II类化合物的组合物和方法公开(公告)号：US08314210B2
公开(公告)日：2012-11-20
申请号：US10617568
申请日：2003-07-11
申请人： Kai W. Wucherpfennig , Nilufer Seth
发明人： Kai W. Wucherpfennig , Nilufer Seth
CPC分类号： C07K14/70539
摘要： The present invention relates to novel compositions and methods for the generation of MHC class II compounds. Such methods are useful in identifying antigen-specific T cells, regulating an immune response and treating subjects suffering from an immune disorder.
摘要翻译： 本发明涉及用于产生MHC II类化合物的新型组合物和方法。 这样的方法可用于鉴定抗原特异性T细胞，调节免疫应答并治疗患有免疫疾病的受试者。
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公开(公告)号：US08148084B2
公开(公告)日：2012-04-03
申请号：US11766608
申请日：2007-06-21
申请人： Kevin C. O'Connor , David A. Hafler , Kai W. Wucherpfennig , Katherine McLaughlin , William H. Robinson , Lawrence Steinman
发明人： Kevin C. O'Connor , David A. Hafler , Kai W. Wucherpfennig , Katherine McLaughlin , William H. Robinson , Lawrence Steinman
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , A61K35/16 , C07K14/36 , C07K14/4713 , C07K14/70503 , C07K14/70507 , G01N2800/24 , G01N2800/285
摘要： Methods and compositions for diagnosing and treating autoimmune disease, e.g., acute disseminated encephalomyelitis (ADEM), are described.
摘要翻译： 描述了用于诊断和治疗自身免疫性疾病例如急性播散性脑脊髓炎（ADEM）的方法和组合物。
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公开(公告)号：US20090054251A1
公开(公告)日：2009-02-26
申请号：US11766608
申请日：2007-06-21
申请人： Kevin C. O'Connor , David A. Hafler , Kai W. Wucherpfennig , Katherine McLaughlin , William H. Robinson , Lawrence Steinman
发明人： Kevin C. O'Connor , David A. Hafler , Kai W. Wucherpfennig , Katherine McLaughlin , William H. Robinson , Lawrence Steinman
IPC分类号： C40B30/04 , G01N33/564
CPC分类号： G01N33/564 , A61K35/16 , C07K14/36 , C07K14/4713 , C07K14/70503 , C07K14/70507 , G01N2800/24 , G01N2800/285
摘要： Methods and compositions for diagnosing and treating autoimmune disease, e.g., acute disseminated encephalomyelitis (ADEM), are described.
摘要翻译： 描述了用于诊断和治疗自身免疫性疾病例如急性播散性脑脊髓炎（ADEM）的方法和组合物。
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公开(公告)号：US07255861B1
公开(公告)日：2007-08-14
申请号：US08991628
申请日：1997-11-05
CPC分类号： A61K39/0008 , A61K39/00 , C07K7/08 , C07K14/005 , C07K14/4713 , C07K14/70539 , C12N2710/10322 , C12N2710/16222 , C12N2710/16622 , C12N2710/20022 , C12N2720/12022 , C12N2760/16122 , G01N33/564 , G01N33/6878 , G01N2800/285
摘要： The present invention provides isolated peptides relating to the autoimmune diseases pemphigus vulgaris and multiple sclerosis. The peptides relating to pemphigus vulgaris are self epitopes and those relating to multiple sclerosis are foreign antigens derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharamaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharamaceutical preparations and methods of use for these epitopes are also provided.
摘要翻译： 本发明提供了与自身免疫疾病寻常型天疱疮和多发性硬化相关的分离的肽。 与寻常型天疱疮有关的肽是自身表位，与多发性硬化相关的肽是来自人类病原体的外来抗原，其涉及病因和疾病的缓解。 提供了用于容忍和/或免疫个体的药物制剂以及与其有关的方法。 提供了用于鉴定涉及人自身免疫疾病的其他自身和非自身表位的方法和类似的药物制剂，并且还提供了这些表位的使用方法。
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