公开(公告)号：US20140212402A1

公开(公告)日：2014-07-31

申请号：US14197347

申请日：2014-03-05

Applicant: Kaneka Corporation

Inventor： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: A61K31/122 ,  A61K47/10 ,  A61K47/12

CPC classification number: A61K31/122 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  B01D9/00 ,  C07C41/26 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23

Abstract: The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with, an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10 in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.

Abstract translation: 本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定保健食品等有用。 此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制，可以处理和稳定地保存还原型辅酶Q10，从而获得稳定的组合物。 此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等存在下使还原型辅酶Q10结晶化，从而使作为副产物的氧化型辅酶Q10的形成最小化， 生产高品质的辅酶Q10晶体。 此外，通过使用抗坏血酸或其相关化合物将氧化型辅酶Q 10还原为还原型辅酶Q10后，在抗坏血酸或其相关化合物存在下，依次结晶生成的还原型辅酶Q10，操作简化，最小化，因此减少了辅酶Q10 生产高品质。

公开(公告)号：US09532957B2

公开(公告)日：2017-01-03

申请号：US14197347

申请日：2014-03-05

Applicant: Kaneka Corporation

Inventor： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: A61K31/122 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  B01D9/00 ,  C07C41/26 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23 ,  A61K9/48

CPC classification number: A61K31/122 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  B01D9/00 ,  C07C41/26 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23

Abstract: The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with, an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10 in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.

Abstract translation: 本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定健康食品等有用。 此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制，可以处理和稳定地保存还原型辅酶Q10，从而获得稳定的组合物。 此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等存在下使还原型辅酶Q10结晶化，从而使作为副产物的氧化型辅酶Q10的形成最小化， 生产高品质的辅酶Q10晶体。 此外，通过使用抗坏血酸或其相关化合物将氧化型辅酶Q 10还原为还原型辅酶Q10后，在抗坏血酸或其相关化合物存在下，依次结晶生成的还原型辅酶Q10，操作简化，最小化，因此减少了辅酶Q10 生产高品质。