公开(公告)号：US20210046144A1

公开(公告)日：2021-02-18

申请号：US16977353

申请日：2019-03-01

Applicant: Kansas State University Research Foundation

Inventor： Megan C. Niederwerder ,  Raymond R.R. Rowland ,  Cassandra Jones ,  Steven S. Dritz ,  Jason C. Woodworth

IPC: A61K36/9066 ,  A61K31/20 ,  A61K36/88 ,  A61K36/81 ,  A61K36/537 ,  A61P31/20 ,  A23K20/158 ,  A23K50/42 ,  A23K20/22 ,  A23K50/30

Abstract: Methods of inhibiting the spread of African swine fever virus and/or classical swine fever virus in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids. The chemical mitigants are effective when introduced to the feed or feed ingredients at inclusion rates much lower than previous methods for inhibiting other microbes. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.

公开(公告)号：US20210188939A1

公开(公告)日：2021-06-24

申请号：US16756756

申请日：2018-10-16

Applicant: Kansas State University Research Foundation

Inventor： Raymond R.R. Rowland ,  Ana Stoian

IPC: C07K14/705 ,  C12N15/85 ,  A01K67/027

Abstract: The present disclosure provides compositions and methods for decreasing permissiveness to infection by PRRSV. The methods involve inserting peptides or oligopeptides into the CD163 SRCR domain 5 to disrupt the protein structure and thereby prevent PRRSV infection. The deletion of the exon 13 region of PSTII eliminates infection. The replacement of cysteine residues with alanines in SRCR5 as a means to disrupt disulfide bond formation. The final method is the deletion of, or amino acid substitution within the SRCR4-5 interdomain region.

公开(公告)号：US20240343774A1

公开(公告)日：2024-10-17

申请号：US18758151

申请日：2024-06-28

Applicant: Kansas State University Research Foundation

Inventor： Raymond R.R. Rowland ,  Ana Stoian

IPC: C07K14/705 ,  A01K67/027 ,  C12N15/85

CPC classification number: C07K14/705 ,  A01K67/027 ,  C12N15/85

Abstract: The present disclosure provides compositions and methods for decreasing permissiveness to infection by PRRSV. The methods involve inserting peptides or oligopeptides into the CD163 SRCR domain 5 to disrupt the protein structure and thereby prevent PRRSV infection. The deletion of the exon 13 region of PSTII eliminates infection. The replacement of cysteine residues with alanines in SRCR5 as a means to disrupt disulfide bond formation. The final method is the deletion of, or amino acid substitution within the SRCR4-5 interdomain region.

公开(公告)号：US20240066093A1

公开(公告)日：2024-02-29

申请号：US18502985

申请日：2023-11-06

Applicant: Kansas State University Research Foundation

Inventor： Megan C. Niederwerder ,  Raymond R.R. Rowland ,  Cassandra Jones ,  Steven S. Dritz ,  Jason C. Woodworth

IPC: A61K36/9066 ,  A23K20/158 ,  A23K20/22 ,  A23K50/30 ,  A23K50/42 ,  A61K31/20 ,  A61K36/537 ,  A61K36/81 ,  A61K36/88 ,  A61P31/20

CPC classification number: A61K36/9066 ,  A23K20/158 ,  A23K20/22 ,  A23K50/30 ,  A23K50/42 ,  A61K31/20 ,  A61K36/537 ,  A61K36/81 ,  A61K36/88 ,  A61P31/20

Abstract: Methods of inhibiting the spread of African swine fever virus and/or classical swine fever virus in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids. The chemical mitigants are effective when introduced to the feed or feed ingredients at inclusion rates much lower than previous methods for inhibiting other microbes. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.