公开(公告)号：US20220175661A1

公开(公告)日：2022-06-09

申请号：US17442349

申请日：2020-03-25

Applicant: Kansas State University Research Foundation

Inventor： Viktor Chikan ,  Ryan Rafferty

IPC: A61K9/00 ,  A61K41/00 ,  A61N2/00 ,  C12N13/00

Abstract: Methods for enhancing intracellular uptake of active agents by inducing temporary pore formation in a cell membrane are described. The methods generally comprise introducing nanoparticles to a cell in vivo, ex vivo, or in cell culture to magnetic nanoparticles that are taken up into the cell interior. The methods further comprise introducing active agents to the cell. A magnetic field is applied to the cell for targeted excitation of the internalized magnetic nanoparticles to induce temporary pore formation in the cell membrane, such that the active agent is taken up in an increased amount and/or at an increased rate by the cell.