公开(公告)号：US07662826B2

公开(公告)日：2010-02-16

申请号：US10511840

申请日：2003-04-18

申请人： Kaoru Seno ,  Koichi Nishi ,  Yoshiyuki Matsuo ,  Toshio Fujishita

发明人： Kaoru Seno ,  Koichi Nishi ,  Yoshiyuki Matsuo ,  Toshio Fujishita

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P27/02 ,  A61P29/00 ,  A61P43/00

CPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/5377 ,  C07D487/04

摘要： A compound represented by the formula (Ia) (wherein R1a, R2a, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or solvate thereof. The compounds are useful in the prevention of or treatment for diseases relating to NAD(P)H.

摘要翻译： 由式（Ia）表示的化合物（其中R1a，R2a和R3至R5与说明书中定义相同），其前药，其药学上可接受的盐或其溶剂化物。 该化合物可用于预防或治疗与NAD（P）H有关的疾病。

公开(公告)号：US20060089362A1

公开(公告)日：2006-04-27

申请号：US10511840

申请日：2003-04-18

申请人： Kaoru Seno ,  Koichi Nishi ,  Yoshiyuki Matsuo ,  Toshio Fujishita

发明人： Kaoru Seno ,  Koichi Nishi ,  Yoshiyuki Matsuo ,  Toshio Fujishita

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/5377 ,  C07D487/04

摘要： A compound represented by the formula (Ia) (wherein R1a, R2a, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or solvate thereof. The compounds are useful in the prevention of or treatment for diseases relating to NAD(P)H.

摘要翻译： 由式（Ia）表示的化合物（其中R1a，R2a和R3至R5与说明书中定义相同），其前药，其药学上可接受的盐或其溶剂化物。 该化合物可用于预防或治疗与NAD（P）H相关的疾病。

公开(公告)号：US4734726A

公开(公告)日：1988-03-29

申请号：US38980

申请日：1987-04-16

申请人： Akira Takahashi ,  Saburo Sasaki ,  Koichi Nishi ,  Shinichiro Koshiishi

发明人： Akira Takahashi ,  Saburo Sasaki ,  Koichi Nishi ,  Shinichiro Koshiishi

IPC分类号： G02B7/08 ,  G02B7/28 ,  G03B3/10 ,  G03B5/00 ,  G03B17/04 ,  G03B17/12

CPC分类号： G03B17/04 ,  G03B3/10

摘要： An apparatus for moving a lens between first and second positions, comprising; a support member means for supporting said lens, an electric motor connected to said support member means for moving said support member, a control circuit means connected to said motor for supplying a first current to said motor to move said support member means from said first position to said second position and vice versa and a second current to said motor to hold said support member means at least one of said first position and second position, said second current being smaller than said first current.

摘要翻译： 一种用于在第一和第二位置之间移动透镜的装置，包括： 用于支撑所述透镜的支撑构件装置，连接到用于移动所述支撑构件的所述支撑构件装置的电动机;连接到所述电动机的控制电路装置，用于向所述电动机提供第一电流，以使所述支撑构件装置从所述第一位置 到所述第二位置，反之亦然，并且向所述电动机施加第二电流以将所述支撑构件装置保持在所述第一位置和第二位置中的至少一个上，所述第二电流小于所述第一电流。

公开(公告)号：US08952176B2

公开(公告)日：2015-02-10

申请号：US11916173

申请日：2006-06-06

申请人： Tomoyuki Ogawa ,  Noriyuki Kurose ,  Satoru Tanaka ,  Koichi Nishi

发明人： Tomoyuki Ogawa ,  Noriyuki Kurose ,  Satoru Tanaka ,  Koichi Nishi

IPC分类号： C07D261/12 ,  C07D261/18 ,  C07D413/12 ,  C07D261/10 ,  C07D413/06 ,  C07D413/14 ,  C07D417/12 ,  C07D471/10 ,  C07D487/08

CPC分类号： C07D261/10 ,  C07D261/18 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/10 ,  C07D487/08

摘要： Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl or the like, One of R2 and R3 is a group of the formula: —C(═O)—Y—R4, wherein Y is —NR9— or the like, R4 is optionally substituted cycloalkyl or the like, R9 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, The other is a group of the formula: —V—R5, wherein V is a bond, —O— or the like, R6 is hydrogen or optionally substituted alkyl, R5 is hydrogen, optionally substituted alkyl or the like, X is a bond, —S—, —SO— or the like, U is a bond or optionally substituted alkylene, R7 is hydrogen or optionally substituted alkyl, Z is —S—, —O— or —NR8—, R8 is hydrogen, optionally substituted alkyl or the like.

摘要翻译： 公开了可用作I 11和Bgr的羟基类固醇脱氢酶抑制剂的化合物。 由下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是任选取代的环烷基，任选取代的环烯基等，R 2和R 3中的一个是下式的基团：-C（= O）-Y- R4，其中Y是-NR9-等，R4是任选取代的环烷基等，R 9是氢或任选取代的烷基，W是任选取代的亚烷基，另一个是下式基团：-V-R5，其中 V是键，-O-等，R6是氢或任选取代的烷基，R 5是氢，任选取代的烷基等，X是一个键，-S-，-SO-等，U是 键或任选取代的亚烷基，R 7是氢或任选取代的烷基，Z是-S-，-O-或-NR 8 - ，R 8是氢，任选取代的烷基等。

公开(公告)号：US20100197662A1

公开(公告)日：2010-08-05

申请号：US11916173

申请日：2006-06-06

申请人： Tomoyuki Ogawa ,  Noriyuki Kurose ,  Satoru Tanaka ,  Koichi Nishi

发明人： Tomoyuki Ogawa ,  Noriyuki Kurose ,  Satoru Tanaka ,  Koichi Nishi

IPC分类号： A61K31/55 ,  C07D261/10 ,  A61K31/42 ,  C07D413/06 ,  C07D261/18 ,  A61K31/4439 ,  C07D413/12 ,  A61K31/454 ,  A61K31/538 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/529 ,  C07D453/02 ,  A61K31/439 ,  C07D413/14 ,  A61P3/10

CPC分类号： C07D261/10 ,  C07D261/18 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/10 ,  C07D487/08

摘要： Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl or the like, One of R2 and R3 is a group of the formula: —C(═O)—Y—R4, wherein Y is —NR9— or the like, R4 is optionally substituted cycloalkyl or the like, R9 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, The other is a group of the formula: —V—R5, wherein V is a bond, —O— or the like, R6 is hydrogen or optionally substituted alkyl, R5 is hydrogen, optionally substituted alkyl or the like, X is a bond, —S—, —SO— or the like, U is a bond or optionally substituted alkylene, R7 is hydrogen or optionally substituted alkyl, Z is —S—, —O— or —NR8—, R8 is hydrogen, optionally substituted alkyl or the like.

摘要翻译： 公开了可用作I 11和Bgr的羟基类固醇脱氢酶抑制剂的化合物。 由下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是任选取代的环烷基，任选取代的环烯基等，R 2和R 3中的一个是下式的基团：-C（= O）-Y- R4，其中Y是-NR9-等，R4是任选取代的环烷基等，R 9是氢或任选取代的烷基，W是任选取代的亚烷基，另一个是下式基团：-V-R5，其中 V是键，-O-等，R6是氢或任选取代的烷基，R 5是氢，任选取代的烷基等，X是一个键，-S-，-SO-等，U是 键或任选取代的亚烷基，R 7是氢或任选取代的烷基，Z是-S-，-O-或-NR 8 - ，R 8是氢，任选取代的烷基等。

公开(公告)号：USRE33436E

公开(公告)日：1990-11-13

申请号：US204011

申请日：1988-06-08

申请人： Kunihiko Araki ,  Susumu Iguchi ,  Tadafumi Ohguro ,  Yoshimi Ono ,  Koichi Nishi ,  Yoshio Fukushima ,  Satoshi Yamane ,  Hirofumi Horigome

发明人： Kunihiko Araki ,  Susumu Iguchi ,  Tadafumi Ohguro ,  Yoshimi Ono ,  Koichi Nishi ,  Yoshio Fukushima ,  Satoshi Yamane ,  Hirofumi Horigome

IPC分类号： G03B17/42

CPC分类号： G03B17/425

摘要： A film advancing system of a camera in which a roll of film inside a film cartridge is first wound to a spool and then the film is rewound into the cartridge one frame from another after each photographic operation is provided. The system includes a reversibly rotatable motor the drivement and rotational direction of which are automatically controlled depending upon various conditions of the camera to implement required advancement of the film.

公开(公告)号：US4460256A

公开(公告)日：1984-07-17

申请号：US323686

申请日：1981-11-20

申请人： Kunihiko Araki ,  Susumu Iguchi ,  Tadafumi Ohguro ,  Yoshimi Ono ,  Koichi Nishi ,  Yoshio Fukushima ,  Satoshi Yamane ,  Hirofumi Horigome

发明人： Kunihiko Araki ,  Susumu Iguchi ,  Tadafumi Ohguro ,  Yoshimi Ono ,  Koichi Nishi ,  Yoshio Fukushima ,  Satoshi Yamane ,  Hirofumi Horigome

IPC分类号： G03B17/42 ,  G03B1/18 ,  G03B1/66 ,  G03B17/36

CPC分类号： G03B17/425

摘要： A film advancing system of a camera in which a roll of film inside a film cartridge is first wound to a spool and then the film is rewound into the cartridge one frame from another after each photographic operation is provided. The system includes a reversibly rotatable motor the drivement and rotational direction of which are automatically controlled depending upon various conditions of the camera to implement required advancement of the film.

摘要翻译： 一种照相机的胶卷推进系统，其中胶片暗盒内的一卷胶片首先卷绕到卷轴上，然后在提供每次照相操作之后，将胶片从另一张框架中重新卷入到盒中。 该系统包括可逆转的电动机，其驱动和旋转方向根据相机的各种条件自动控制以实现胶片的所需进展。

公开(公告)号：US06576446B2

公开(公告)日：2003-06-10

申请号：US09875963

申请日：2001-06-08

申请人： Hiroshi Yamasaki ,  Koichi Nishi ,  Toshio Miyake

发明人： Hiroshi Yamasaki ,  Koichi Nishi ,  Toshio Miyake

IPC分类号： C12P1944

CPC分类号： C07H17/04

摘要： Disclosed is a process for producing a high &agr;G-AA content product, which comprises the steps of: contacting a solution as a material solution, containing &agr;G-AA, L-ascorbic acid, and a saccharide(s), with an anion exchange resin packed in a column to adsorb the &agr;G-AA and L-ascorbic acid on the anion exchanger; washing the anion exchanger with water to remove the saccharide(s) therefrom; feeding to the column an aqueous solution, as an eluent, of an acid and/or a salt with a concentration of less than 0.5 N to fractionate a fraction rich in 2-O-&agr;-D-glucopyranosyl-L-ascorbic acid and a fraction rich in L-ascorbic acid; and collecting the former fraction.

摘要翻译： 公开了一种制备高αG-AA含量产物的方法，其包括以下步骤：使含有αG-AA，L-抗坏血酸和糖的溶液与阴离子交换树脂接触 填充在柱中以吸附阴离子交换剂上的αG-AA和L-抗坏血酸; 用水洗涤阴离子交换剂以除去其中的糖类; 向柱中加入浓度小于0.5N的酸和/或盐的水溶液作为洗脱剂，以分级富含2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的级分和 级分富含L-抗坏血酸; 并收集前一部分。

公开(公告)号：US5338733A

公开(公告)日：1994-08-16

申请号：US39957

申请日：1993-03-30

申请人： Mitsuru Imuta ,  Koichi Nishi

发明人： Mitsuru Imuta ,  Koichi Nishi

IPC分类号： A61K31/40 ,  A61K31/397 ,  A61K31/407 ,  A61K31/42 ,  A61K31/422 ,  A61P31/04 ,  C07D477/00 ,  C07D477/14 ,  C07D487/00 ,  A01N43/00 ,  A61K31/395

CPC分类号： C07D477/14 ,  Y02P20/55

摘要： A carbapenem derivative represented by Formula I: ##STR1## wherein R.sup.1 is hydrogen or a hydroxy protecting group; R.sup.2 is substituted or non-substituted lower alkyl; R.sup.3 is hydrogen, an inorganic or organic base, or a carboxy protecting group; and R.sup.4 is a compound represented by any of the following Formulae II through V: ##STR2## wherein R.sup.5 and R.sup.6 are independently substituted or non-substituted lower alkyl.

摘要翻译： 由式I表示的碳青霉烯衍生物：xy保护基; R2是取代或未取代的低级烷基; R3是氢，无机或有机碱或羧基保护基; （IV）其中R 5和R 6独立地是取代或未取代的，并且R 4是由下式II至V中的任一个表示的化合物： 取代的低级烷基。

公开(公告)号：USRE32850E

公开(公告)日：1989-01-31

申请号：US839045

申请日：1989-01-31

申请人： Kunihiko Araki ,  Susumu Iguchi ,  Tadafumi Ohguro ,  Yoshimi Ono ,  Koichi Nishi ,  Yoshio Fukushima ,  Satoshi Yamane ,  Hirofumi Horigome

发明人： Kunihiko Araki ,  Susumu Iguchi ,  Tadafumi Ohguro ,  Yoshimi Ono ,  Koichi Nishi ,  Yoshio Fukushima ,  Satoshi Yamane ,  Hirofumi Horigome

IPC分类号： G03B17/42

CPC分类号： G03B17/425

摘要： A film advancing system of a camera in which a roll of film inside a film cartridge is first wound to a spool and then the film is rewound into the cartridge one frame from another after each photographic operation is provided. The system includes a reversibly rotatable motor the drivement and rotational direction of which are automatically controlled depending upon various conditions of the camera to implement required advancement of the film.