摘要:
There is provided stereoselective route to a compound of formula I: wherein R represents H or an alkali metal, Ar1 represents 4-chlorophenyl and Ar2 represents 2,5-difluorophenyl.
摘要:
A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
摘要:
A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
摘要:
The present invention is a method and apparatus for processing image data to accomplish tuning or adjustment of images, so as to modify at least the darkness thereof, using compact, efficient methods and designs.
摘要:
An image forming device may select from among a plurality of rendering parameters to include selectable halftone frequency candidates automatically based on an internal determination regarding an operating condition of the device to improve image quality for formed images. As a time varying function of the status and/or condition of the components and/or consumables employed in the image forming device, a capability is provided for the device to independently determine an optimal individual or set of rendering parameters to be employed based on a monitored device status. Available monitoring data for a current overall condition of the image forming device, to include monitoring a condition of the components and/or the consumables within the device, is used to allow the device to internally perform automatic adjustment of one or more image rendering parameters, including automatically implementing an optimal halftone frequency election scheme.
摘要:
An image forming device may select from among a plurality of rendering parameters to include selectable halftone frequency candidates automatically based on an internal determination regarding an operating condition of the device to improve image quality for formed images. As a time varying function of the status and/or condition of the components and/or consumables employed in the image forming device, a capability is provided for the device to independently determine an optimal individual or set of rendering parameters to be employed based on a monitored device status. Available monitoring data for a current overall condition of the image forming device, to include monitoring a condition of the components and/or the consumables within the device, is used to allow the device to internally perform automatic adjustment of one or more image rendering parameters, including automatically implementing an optimal halftone frequency election scheme.
摘要:
One aspect of the invention provides a method of halftoning an image which involves determining a quantization error for a selected target pixel of an image, selecting a diffusion mask, the mask relating to the target pixel and pixels neighboring thereto, receiving a first pair of neighboring pixel values for a first pixel pair including a first neighboring pixel and a second neighboring pixel, and receiving a second pair of neighboring pixel values for a second pixel pair including a third neighboring pixel and a fourth neighboring pixel. The method further involves determining a ranking order of the first, second, third and fourth neighboring pixels by comparing pixel values of the first, second, third and fourth neighboring pixels, and diffusing error to at least one of the first, second, third and fourth neighboring pixels based on the determined ranking order of the first, second, third and fourth neighboring pixels.
摘要:
Methods and apparatus are disclosed for causing the optical center of the eye to align “HIGH point” of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a “bounded region.” For corneal ablation procedures, the “bounded region” comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a “great circle” are formed in the cornea to weaken and flatten it. As used herein, a “great circle” is formed by a plane containing the HIGH point and parallel to the local z-axis. The “bounded region” for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.
摘要:
Methods and apparatus are disclosed for causing the optical center of the eye to align "HIGH point" of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a "bounded region." For corneal ablation procedures, the "bounded region" comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a "great circle" are formed in the cornea to weaken and flatten it. As used herein, a "great circle" is formed by a plane containing the HIGH point and parallel to the local z-axis. The "bounded region" for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.
摘要:
Methods and apparatus are disclosed for causing the optical center of the eye to align “HIGH point” of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a “bounded region.” For corneal ablation procedures, the “bounded region” comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a “great circle” are formed in the cornea to weaken and flatten it. As used herein, a “great circle” is formed by a plane containing the HIGH point and parallel to the local z-axis. The “bounded region” for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.