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公开(公告)号：US4002763A
公开(公告)日：1977-01-11
申请号：US532191
申请日：1974-12-12
IPC分类号： C07D249/08 , A61K31/41
CPC分类号： C07C45/71 , C07C45/004 , C07C45/63 , C07C45/70 , C07D249/08
摘要： Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein X.sup.1 is hydrogen or alkyl;X.sup.2 is hydrogen or alkyl;R.sup.1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl;R.sup.3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; andY is a keto group of a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.
摘要翻译： 产生抗真菌组合物，其包含抗真菌有效量的下式的1,2,4-三唑或其药学上可接受的无毒盐，其中X 1是氢或烷基; X2是氢或烷基; R1是烷基，未取代或取代的芳基或未取代或取代的芳烷基; R2是氢，烷基或未取代或取代的芳基; R3是烷基，环烷基，未取代或取代的芳基或未取代或取代的芳烷基; 和Y是酮基的功能性衍生物的酮基，其与药学上可接受的无毒惰性稀释剂或载体的组合。
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2.发明授权1-Propyl-triazolyl antimycotic compositions and methods of treating mycoses 失效1-丙基 - 三唑基抗真菌组合物和治疗真菌病的方法
公开(公告)号：US4079142A
公开(公告)日：1978-03-14
申请号：US638754
申请日：1975-12-08
IPC分类号： C07D249/08 , A61K31/41
CPC分类号： C07D249/08
摘要： Pharmaceutical compositions are produced which comprise an antimycotically effective amount of a compound of the formula ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein R.sup.1 is an unsubstituted or substituted aryl moiety,R.sup.2 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.3 is hydrogen, alkyl or cycloalkyl,Provided that when R.sup.3 is hydrogen, R.sup.2 cannot be hydrogen, in combination with a pharmaceutically acceptable non-toxic inert diluent or carrier.
摘要翻译： 制备药物组合物，其包含抗真菌有效量的下式化合物或其药学上可接受的无毒盐，其中R 1是未取代或取代的芳基部分，R 2是氢，烷基，烯基，环烷基，未取代的或未取代的 取代的芳基或未取代或取代的芳烷基，并且R 3是氢，烷基或环烷基，当R3是氢时，R2不能是氢，与药学上可接受的无毒惰性稀释剂或载体组合。
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公开(公告)号：US4038406A
公开(公告)日：1977-07-26
申请号：US645563
申请日：1975-12-31
IPC分类号： C07D249/08 , A61K31/41
CPC分类号： C07C45/63 , C07C45/004 , C07C45/70 , C07C45/71 , C07D249/08
摘要： Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein X.sup.1 is hydrogen or alkyl;X.sup.2 is hydrogen or alkyl;R.sup.1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl;R.sup.3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; andY is a keto group or a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.
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4.发明授权1-Propyl-imidazolyl antimycotic compositions and methods of treating mycoses 失效1-丙氧基咪唑类抗生素组合物及其治疗方法
公开(公告)号：US3987180A
公开(公告)日：1976-10-19
申请号：US508685
申请日：1974-09-23
IPC分类号： C07D233/60 , C07D521/00 , A61K31/415
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Pharmaceutical compositions are produced which comprise an antimycotically effective amount of a compound of the formula ##EQU1## or a pharmaceutically acceptable non-toxic salt thereof wherein R.sup.1 is an unsubstituted or substituted aryl moiety,R.sup.2 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.3 is hydrogen, alkyl or cycloalkyl,Provided that when R.sup.3 is hydrogen, R.sup.2 cannot be hydrogen, in combination with a pharmaceutically acceptable non-toxic inert diluent or carrier.
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公开(公告)号：US3949080A
公开(公告)日：1976-04-06
申请号：US465617
申请日：1974-04-30
IPC分类号： C07D249/04 , A01N43/647 , A01N43/653 , A61K31/41 , A61P31/04 , A61P31/10 , C07D233/60 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Pharmaceutical compositions comprising a triazolyl-O,N-acetal as the active ingredient and method of using same. The said compositions are useful as antimicrobials and are especially useful as antimycotic agents.
摘要翻译： 包含三唑基-O，N-缩醛作为活性成分的药物组合物及其使用方法。 所述组合物可用作抗微生物剂，并且特别可用作抗真菌剂。
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公开(公告)号：US4060623A
公开(公告)日：1977-11-29
申请号：US646019
申请日：1976-01-02
IPC分类号： C07D249/08 , A61K31/41
CPC分类号： C07C45/71 , C07C45/004 , C07C45/63 , C07C45/70 , C07D249/08
摘要： Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein X.sup.1 is hydrogen or alkyl;X.sup.2 is hydrogen or alkyl;R.sup.1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl;R.sup.3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; andY is a keto group or a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.
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公开(公告)号：US4038404A
公开(公告)日：1977-07-26
申请号：US646056
申请日：1976-01-02
IPC分类号： C07D249/08
CPC分类号： C07C45/63 , C07C45/004 , C07C45/70 , C07C45/71 , C07D249/08
摘要： Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein X.sup.1 is hydrogen or alkyl;X.sup.2 is hydrogen or alkyl;R.sup.1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl;R.sup.3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; andY is a keto group or a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.
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公开(公告)号：US4036967A
公开(公告)日：1977-07-19
申请号：US645946
申请日：1976-01-02
IPC分类号： C07D249/08 , A61K31/41
CPC分类号： C07C45/63 , C07C45/004 , C07C45/70 , C07C45/71 , C07D249/08
摘要： Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein X.sup.1 is hydrogen or alkyl;X.sup.2 is hydrogen or alkyl;R.sup.1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl;R.sup.3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; andY is a keto group or a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.
摘要翻译： 产生抗真菌组合物，其包含抗真菌有效量的下式的1,2,4-三唑或其药学上可接受的无毒盐，其中X 1是氢或烷基; X2是氢或烷基; R1是烷基，未取代或取代的芳基或未取代或取代的芳烷基; R2是氢，烷基或未取代或取代的芳基; R3是烷基，环烷基，未取代或取代的芳基或未取代或取代的芳烷基; 和Y是酮基或酮基的官能衍生物，与药学上可接受的无毒惰性稀释剂或载体组合。
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公开(公告)号：US4036966A
公开(公告)日：1977-07-19
申请号：US646192
申请日：1976-01-02
IPC分类号： C07D249/08 , A61K31/41
CPC分类号： C07C45/63 , C07C45/004 , C07C45/70 , C07C45/71 , C07D249/08
摘要： Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein X.sup.1 is hydrogen or alkyl;X.sup.2 is hydrogen or alkyl;R.sup.1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl;R.sup.3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; andY is a keto group or a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.
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10.发明授权1-Propyl-triazolyl antimycotic compositions and methods of treating mycoses 失效1-丙基 - 三唑基抗真菌组合物和治疗真菌病的方法
公开(公告)号：US3993765A
公开(公告)日：1976-11-23
申请号：US508684
申请日：1974-09-23
IPC分类号： C07C45/63 , C07C45/71 , C07C45/75 , C07C49/255 , C07D249/08 , C07D521/00 , A61K31/41
CPC分类号： C07D231/12 , C07C45/63 , C07C45/71 , C07C45/75 , C07C49/255 , C07D233/56 , C07D249/08
摘要： Pharmaceutical compositions are produced which comprise an antimycotically effective amount of a compound of the formula ##SPC1##Or a pharmaceutically acceptable non-toxic salt thereof whereinR.sup.1 is an unsubstituted or substituted aryl moiety,R.sup.2 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.3 is hydrogen, alkyl or cycloalkyl,Provided that when R.sup.3 is hydrogen, R.sup.2 cannot be hydrogen, in combination with a pharmaceutically acceptable nontoxic inert diluent or carrier.
摘要翻译： 制备药物组合物，其包含抗真菌有效量的式+ q，10或其药学上可接受的非毒性盐的化合物，其中R1是未取代或取代的芳基部分，R2是氢，烷基，烯基，环烷基，未取代的 或取代的芳基或未取代或取代的芳烷基，并且R 3为氢，烷基或环烷基，当R3为氢时，R2不能为氢，与药学上可接受的无毒惰性稀释剂或载体组合。
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