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    Production of Solid Solutions Based on Poorly-Soluble Active Substances by a Short-Term Heating and Rapid Drying
    5.
    发明申请
    Production of Solid Solutions Based on Poorly-Soluble Active Substances by a Short-Term Heating and Rapid Drying 审中-公开
    通过短期加热和快速干燥生产基于不良溶解活性物质的固体溶液

    公开(公告)号：US20080248117A1

    公开(公告)日：2008-10-09

    申请号：US11916074

    申请日：2006-05-31

    申请人： Karl Kolter ,  Michael Schoenherr ,  Hermann Ascherl

    发明人： Karl Kolter ,  Michael Schoenherr ,  Hermann Ascherl

    IPC分类号： A61K9/00

    CPC分类号： A61K9/146 ,  A61K31/07 ,  A61K31/405 ,  A61K31/4174 ,  A61K31/426 ,  A61K31/495 ,  A61K31/496 ,  A61K31/522 ,  A61K31/5415 ,  A61K31/55

    摘要： A process for producing solid solutions in powder or granule form of slightly soluble substances in which the slightly soluble substance is in the form of a molecular dispersion in an excipient matrix, by atomizing a solution of the active ingredient and of the matrix excipients, which comprises heating an aqueous suspension of the slightly soluble substance in the presence of the matrix excipients to temperatures above the boiling point under atmospheric pressure, and dissolving the slightly soluble substance, and subsequently converting the solution of the slightly soluble substance and of the matrix excipients by atomizing and drying into a solid form, where the temperature of the spray solution before feeding into the atomizing apparatus is 90° C. to 350° C.

    摘要翻译： 通过雾化活性成分和基质赋形剂的溶液，其中微溶性物质是赋形剂基质中分子分散体形式的微溶性物质的粉末或颗粒形式的固溶体的方法，其包括 在基质赋形剂存在下将微溶性物质的水性悬浮液加热至高于大气压沸点的温度，并溶解微溶性物质，随后通过雾化将微溶性物质和基质赋形剂的溶液转化 并干燥成固体形式，其中在进入雾化装置之前喷雾溶液的温度为90℃至350℃。

    PROCESS FOR PRODUCING SOLID ORAL DOSAGE FORMS WITH SUSTAINED RELEASE OF ACTIVE INGREDIENT
    8.
    发明申请
    PROCESS FOR PRODUCING SOLID ORAL DOSAGE FORMS WITH SUSTAINED RELEASE OF ACTIVE INGREDIENT 审中-公开
    用于生产具有持续释放活性成分的固体口服剂型的方法

    公开(公告)号：US20080241261A1

    公开(公告)日：2008-10-02

    申请号：US12135580

    申请日：2008-06-09

    申请人： Karl KOLTER ,  Dieter Flick ,  Hermann Ascherl

    发明人： Karl KOLTER ,  Dieter Flick ,  Hermann Ascherl

    IPC分类号： A61K9/14 ,  A61P9/12

    CPC分类号： A61K9/1652 ,  A61K9/1635 ,  A61K9/2027 ,  A61K9/2095

    摘要： The present invention relates to a process for producing solid oral dosage forms with sustained release of active ingredient, comprising at least one active ingredient, a preformulated mixture of polyvinyl acetate and polyvinylpyrrolidone, where appropriate, water-soluble polymers or lipophilic additives and, where appropriate, other conventional excipients, wherein this mixture or parts of this mixture are granulated by heating to from 40° C. to 130° C., and the granules are, after admixture with conventional excipients, subsequently tabletted.

    摘要翻译： 本发明涉及一种生产具有持续释放活性成分的固体口服剂型的方法，其包括至少一种活性成分，聚乙酸乙烯酯和聚乙烯吡咯烷酮的预制混合物，在适当情况下，水溶性聚合物或亲脂性添加剂，以及在适当情况下 ，其它常规赋形剂，其中该混合物或该混合物的一部分通过加热至40℃至130℃而造粒，并且在与常规赋形剂混合后，随后将其压片。

    Process for producing solid oral dosage forms with sustained release of active ingredient
    9.
    发明授权
    Process for producing solid oral dosage forms with sustained release of active ingredient 有权
    用于生产具有持续释放活性成分的固体口服剂型的方法

    公开(公告)号：US07413750B2

    公开(公告)日：2008-08-19

    申请号：US09873431

    申请日：2001-06-05

    申请人： Karl Kolter ,  Dieter Flick ,  Hermann Ascherl

    发明人： Karl Kolter ,  Dieter Flick ,  Hermann Ascherl

    IPC分类号： A61K9/26 ,  A61K9/14 ,  A61K9/16

    CPC分类号： A61K9/1652 ,  A61K9/1635 ,  A61K9/2027 ,  A61K9/2095

    摘要： The present invention relates to a process for producing solid oral dosage forms with sustained release of active ingredient, comprising at least one active ingredient, a preformulated mixture of polyvinyl acetate and polyvinylpyrrolidone, where appropriate, water-soluble polymers or lipophilic additives and, where appropriate, other conventional excipients, wherein this mixture or parts of this mixture are granulated by heating to from 40° C. to 130° C., and the granules are, after admixture with conventional excipients, subsequently tabletted.

    摘要翻译： 本发明涉及一种生产具有持续释放活性成分的固体口服剂型的方法，其包括至少一种活性成分，聚乙酸乙烯酯和聚乙烯吡咯烷酮的预制混合物，在适当情况下，水溶性聚合物或亲脂性添加剂，以及在适当情况下 ，其它常规赋形剂，其中该混合物或该混合物的一部分通过加热至40℃至130℃而造粒，并且在与常规赋形剂混合后，随后将其压片。